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首页> 外文期刊>Journal of applied toxicology >Effects of intrauterine exposure to 2,3 ',4,4 ',5-pentachlorobiphenyl on the reproductive system and sperm epigenetic imprinting of male offspring
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Effects of intrauterine exposure to 2,3 ',4,4 ',5-pentachlorobiphenyl on the reproductive system and sperm epigenetic imprinting of male offspring

机译：宫内暴露于2,3'，4,4'，5-五氯二苯苯基对雄性后代的生殖系统和精子表观印迹的影响

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摘要

Polychlorinated biphenyls (PCBs) are a class of persistent organic environmental pollutants with a total of 209 homologs. The homolog 2,3 ',4,4 ',5-pentachlorobiphenyl (PCB118) is one of the most important dioxin-like PCBs and is highly toxic. PCB118 can accumulate in human tissues, serum and breast milk, which leads to direct exposure of the fetus during development. In the present study, pregnant mice were exposed to 0, 20 and 100 mu g/kg/day of PCB118 during the stage of fetal primordial germ cell migration. Compared with the control group, we found morphological alterations of the seminiferous tubules and a higher sperm deformity rate in the male offspring in the treatment groups. Furthermore, the methylation patterns in the treatment groups of the imprinted genes H19 and Gtl2 in the sperm were altered in the male offspring. We also characterized the disturbance of the expression levels of DNA methyltransferase 1 (Dnmt1), Dnmt3a, Dnmt3b, Dnmt3l, and Uhrf1. The results indicated that intrauterine exposure to low doses of PCB118 could significantly damage the reproductive health of the male offspring. Therefore, attention should be paid to the adverse effects of PCB118 exposure during pregnancy on the reproductive system of male offspring.
机译：多氯联苯（PCBs）是一类持久性有机环境污染物，共有209个同系物。同系物2,3'，4,4'，5-五氯联苯（PCB118）是最重要的二恶英类多氯联苯之一，毒性极高。PCB118可积聚在人体组织、血清和母乳中，导致胎儿在发育过程中直接暴露。在本研究中，怀孕小鼠在胎儿原始生殖细胞迁移阶段暴露于0、20和100μg/kg/天的PCB118。与对照组相比，我们发现治疗组雄性后代的生精小管发生了形态学改变，精子畸形率更高。此外，在雄性后代中，精子中印记基因H19和Gtl2治疗组的甲基化模式发生了改变。我们还描述了DNA甲基转移酶1（Dnmt1）、Dnmt3a、Dnmt3b、Dnmt3l和Uhrf1表达水平的紊乱。结果表明，宫内暴露于低剂量PCB118可显著损害雄性后代的生殖健康。因此，应注意孕期接触PCB118对雄性后代生殖系统的不良影响。

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  • 来源
    《Journal of applied toxicology》 |2020年第10期|共14页
  • 作者

    He Qi-Long; Lyu Tian-Qi; Zhang Yong-Tao; Wang Hai-Quan; Zhou Qian; Zhang Jian-Mei; Liu Yuan-Yuan; Li Jia-Shuo; Jiang Li-Gang; Cheng Dong; Ge Zhao-Jia; Liu Shu-Zhen;

  • 作者单位

    Shandong Normal Univ Coll Life Sci Shandong Prov Key Lab Anim Resistance Biol Jinan 250014;

    Shandong Normal Univ Coll Life Sci Shandong Prov Key Lab Anim Resistance Biol Jinan 250014;

    Shandong Normal Univ Coll Life Sci Shandong Prov Key Lab Anim Resistance Biol Jinan 250014;

    Shandong Normal Univ Coll Life Sci Shandong Prov Key Lab Anim Resistance Biol Jinan 250014;

    Chinese Acad Sci Inst Zool State Key Lab Stem Cell &

    Reprod Biol Beijing Peoples R China;

    Shandong Normal Univ Coll Life Sci Shandong Prov Key Lab Anim Resistance Biol Jinan 250014;

    Shandong Normal Univ Coll Life Sci Shandong Prov Key Lab Anim Resistance Biol Jinan 250014;

    Shandong Normal Univ Coll Life Sci Shandong Prov Key Lab Anim Resistance Biol Jinan 250014;

    Shandong Normal Univ Coll Life Sci Shandong Prov Key Lab Anim Resistance Biol Jinan 250014;

    Shandong Ctr Dis Control &

    Prevent Dept Toxicol Jinan Peoples R China;

    Qingdao Agr Univ Coll Life Sci Inst Reprod Sci Qingdao 266109 Peoples R China;

    Shandong Normal Univ Coll Life Sci Shandong Prov Key Lab Anim Resistance Biol Jinan 250014;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 毒物学（毒理学）;
  • 关键词

    epigenetic modification; imprinted gene; PCB118; reproductive system; testis;

    机译：表观遗传修饰;印记基因;PCB118;生殖系统;睾丸;

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