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首页> 外文期刊>Journal of applied toxicology >Toxicological alterations induced by subacute exposure of silver nanoparticles in Wistar rats
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Toxicological alterations induced by subacute exposure of silver nanoparticles in Wistar rats

机译：Wistar大鼠银纳米粒子亚急性暴露诱导的毒理学改变

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Silver nanoparticles (AgNPs) have become crucial players in the field of medicine and various other industries. AgNPs have a wide array of applications, which includes production of electronic goods, cosmetics, synthesis of dyes, and printing inks, as well as targeted delivery of drugs to specialized cells inside the body. Even though humans readily come in contact with these particles, the organ-specific accumulation and resulting mechanisms of toxicity induced by inhaled AgNPs are still under investigation. The goal of this study was to determine the organ distribution of inhaled AgNPs and investigate the resulting systemic toxicity. To do this, male Wistar rats were exposed by inhalation to AgNPs for 4 hr/day (200 parts per billion/day) for five consecutive days. The nanoparticles were generated using a laser ablation technique using a soft-landing ion mobility (SLIM) instrument. Inductively coupled plasma mass spectrometric (ICP-MS) analysis showed organ-specific accumulation of the nanoparticles, with the highest concentration present in the lungs, followed by the liver and kidneys. Nanoparticle distribution was characterized in the organs using scanning electron microscopy (SEM) and matrix-assisted laser desorption/ionization mass spectrometric (MALDI-MS) imaging. Bone marrow cytotoxicity assay of the cells from the femur of rats showed micronuclei formation and signs of cellular cytotoxicity. Moreover, rats displayed increased levels of circulating lactate and glutathione disulphide (GSSG), as determined by liquid chromatography-mass spectrometry (LC-MS) analysis. Collectively, our observations suggest that inhaled subacute exposure to AgNP results in accumulation of AgNPs in the lungs, liver, and kidneys, preferentially, as well as mediates induced systemic toxicity.
机译：银纳米颗粒（AgNP）已成为医药和其他各种行业的关键参与者。AGNP有着广泛的应用，包括生产电子产品、化妆品、染料合成和印刷油墨，以及将药物定向输送到体内的特殊细胞。尽管人类很容易接触到这些颗粒物，但吸入AgNPs引起的器官特异性积聚和由此产生的毒性机制仍在研究中。本研究的目的是确定吸入AgNPs的器官分布，并调查由此产生的全身毒性。为了做到这一点，雄性Wistar大鼠通过吸入AgNPs连续五天，每天4小时（十亿分之200/天）。纳米颗粒是使用软着陆离子迁移率（SLIM）仪器通过激光烧蚀技术生成的。电感耦合等离子体质谱（ICP-MS）分析显示，纳米粒在器官特异性聚集，肺部浓度最高，其次是肝脏和肾脏。利用扫描电子显微镜（SEM）和基质辅助激光解吸/电离质谱（MALDI-MS）成像技术对器官中的纳米粒子分布进行了表征。大鼠股骨细胞的骨髓细胞毒性试验显示微核形成和细胞毒性迹象。此外，通过液相色谱-质谱（LC-MS）分析，大鼠的循环乳酸和谷胱甘肽二硫化物（GSSG）水平升高。总的来说，我们的观察结果表明，吸入亚急性暴露于AgNP会导致AgNP优先在肺、肝和肾中积聚，并介导诱导的全身毒性。

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