...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of applied toxicology >Novel toxicity of tris(1,3-dichloro-2-propyl) phosphate in adult male rats
【24h】

Novel toxicity of tris(1,3-dichloro-2-propyl) phosphate in adult male rats

机译：成年雄性大鼠三（1,3-二氯-2-丙基）磷酸酯的新毒性

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The widespread use of tris(1,3-dichloro-2-propyl) phosphate (TDCIPP) as a flame retardant has led to its release to the environment. Thus, the toxicological effects of TDCIPP on humans and animals are of importance. For better understanding of its potential toxicities, TDCIPP (250, 500, or 650 mg/kg/day) or vehicle control was administrated orally to adult male Wistar-Imamichi rats for 7 days. After the final administration of compounds, organ weights, histopathology, blood biochemistry, and hematology were examined. Hepatic toxicity was observed at doses >= 500 mg/kg/day of TDCIPP, and renal toxicity was observed at 650 mg/kg/day. The anti-androgenic activity of TDCIPP was previously confirmed in vitro and in vivo, but weights of epididymis, an androgen-dependent organ, were not affected by TDCIPP treatment in adults. Serum alkaline phosphatase activity was significantly decreased in all TDCIPP-treated rats independent of dose. Hemoglobin concentration, hematocrit, red blood cell count, and reticulocyte count were decreased in all TDCIPP-treated rats, but mean corpuscular volume, total iron-binding capacity, and serum iron were normal, suggesting that renal anemia was caused by TDCIPP. Together with previous reports on effects of anti-androgenic substances on red blood cell indices, anemia caused by TDCIPP could be due to its anti-androgenic activity. These considerations will contribute to further assessment of the toxicity of the compound.
机译：三（1,3-二氯-2-丙基）磷酸酯（TDCIPP）作为阻燃剂的广泛使用导致其释放到环境中。因此，TDCIPP对人类和动物的毒理学效应非常重要。为了更好地了解其潜在毒性，对成年雄性Wistar Imamichi大鼠口服TDCIPP（250、500或650 mg/kg/天）或溶媒对照7天。最后一次给药后，检查器官重量、组织病理学、血液生化和血液学。在TDCIPP剂量>=500 mg/kg/天时观察到肝脏毒性，在650 mg/kg/天时观察到肾脏毒性。TDCIPP的抗雄激素活性之前已在体外和体内得到证实，但成年患者的雄激素依赖性器官附睾重量不受TDCIPP治疗的影响。所有经TDCIPP治疗的大鼠的血清碱性磷酸酶活性均显著降低，与剂量无关。所有经TDCIPP治疗的大鼠的血红蛋白浓度、红细胞压积、红细胞计数和网织红细胞计数均降低，但平均红细胞体积、总铁结合能力和血清铁均正常，表明肾性贫血是由TDCIPP引起的。与之前关于抗雄激素物质对红细胞指数影响的报道一起，TDCIPP引起的贫血可能是由于其抗雄激素活性。这些考虑将有助于进一步评估该化合物的毒性。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号