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首页> 外文期刊>Journal of Bioinformatics and Computational Biology >Robustness versus evolvability analysis for regulatory feed-forward loops
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Robustness versus evolvability analysis for regulatory feed-forward loops

机译：监管前源循环的鲁棒性与进化促进性分析

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From the definition, it appears that phenotypic robustness and evolvability of an organism are inversely related to each other. However, a number of studies exploring this question have found conflicting evidences in this regard. This question motivated the current work where we explore the relationship between robustness and evolvability. As a model system, we pick the Feed Forward Loops (FFLs), and develop a framework to characterize their performance in terms of their ability to resist changes to steady state expression (robustness), and their ability to evolve towards novel phenotypes (evolvability). We demonstrate that robustness and evolvability are positively correlated in some FFL topologies. We compare this against other small regulatory topologies, and show that the same trend does not hold among them. We postulate that the ability to positively link robustness and evolvability could be an additional reason for over-representation of FFLs in living organisms, as compared to other regulatory topologies.
机译：从定义来看，一个有机体的表型稳健性和进化性似乎是相互反比的。然而，许多探索这个问题的研究在这方面发现了相互矛盾的证据。这个问题激发了我们当前的工作，我们探索稳健性和可进化性之间的关系。作为一个模型系统，我们选择了前馈回路（FFL），并开发了一个框架来描述它们的性能，即它们抵抗稳态表达变化的能力（鲁棒性），以及它们向新表型进化的能力（可进化性）。我们证明了在某些FFL拓扑中，鲁棒性和可进化性正相关。我们将其与其他小型监管拓扑进行了比较，并表明它们之间不存在相同的趋势。我们假设，与其他调控拓扑相比，将稳健性和进化性积极联系起来的能力可能是活生物体中FFL过度表达的另一个原因。

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