Prokaryote autoimmunity in the context of self-targeting by CRISPR-Cas systems

Lenskaia Tatiana; Boley Daniel

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Prokaryote autoimmunity in the context of self-targeting by CRISPR-Cas systems

机译：CRISPR-CAS系统自我定位背景下的原核性自身免疫

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Prokaryote adaptive immunity (CRISPR-Cas systems) can be a threat to its carriers. We analyze the risks of autoimmune reactions related to adaptive immunity in prokaryotes by computational methods. We found important differences between bacteria and archaea with respect to autoimmunity potential. According to the results of our analysis, CRISPR-Cas systems in bacteria are more prone to self-targeting even though they possess fewer spacers per organism on average than archaea. The results of our study provide opportunities to use self-targeting in prokaryotes for biological and medical applications.

机译：原核生物适应性免疫（CRISPR-Cas系统）可能对其携带者构成威胁。我们通过计算方法分析与原核生物适应性免疫相关的自身免疫反应的风险。我们发现细菌和古细菌在自身免疫潜能方面存在重要差异。根据我们的分析结果，细菌中的CRISPR-Cas系统更容易自我定位，尽管它们平均每个生物体的间隔子比古细菌少。我们的研究结果为在生物和医学应用中使用原核生物自我靶向提供了机会。

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《Journal of Bioinformatics and Computational Biology》 |2020年第5期|共12页
作者
Lenskaia Tatiana; Boley Daniel;
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作者单位

Univ Minnesota Dept Comp Sci &

Engn 4-192 Keller Hall 200 Union St SE Minneapolis MN 55455 USA;

Univ Minnesota Dept Comp Sci &

Engn 4-192 Keller Hall 200 Union St SE Minneapolis MN 55455 USA;

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原文格式 PDF
正文语种 eng
中图分类细胞生物学;
关键词
Genome dictionary; computational methods; spacer memory;

机译：基因组词典;计算方法;垫片内存;

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专利

1. A simple, flexible and high-throughput cloning system for plant genome editing via CRISPR-Cas system [J] . Hyeran Kim, Sang-Tae Kim, Jahee Ryu, 植物学报（英文版） . 2016,第008期
2. Harnessing CRISPR-Cas system diversity for gene editing technologies [J] . Alexander McKay, Gaetan Burgio 生物医学研究杂志：英文版 . 2021,第002期
3. Harnessing CRISPR-Cas system diversity for gene editing technologies [J] . Alexander McKay, Gaetan Burgio 生物医学研究杂志（英文版） . 2021,第002期
4. CRISPR-Cas System for RNA Detection and Imaging [J] . CHEN Siyu, WANG Rujia, LEI Chunyang, 高等学校化学研究（英文版） . 2020,第002期
5. Anti-CRISPRs: The natural inhibitors for CRISPR-Cas systems [J] . Fei Zhang, Guoxu Song, Yong Tian 动物模型与实验医学（英文） . 2019,第002期
6. Adaptation induced by self-targeting in a type I-B CRISPR-Cas system [J] . Aris-Edda Stachler, Julia W?rtz, Omer S. Alkhnbashi, The Journal of biological chemistry . 2020,第39期

机译：在I-B型CISCR-CAS系统中自定位引起的适应
7. Outcomes and characterization of chromosomal self-targeting by native CRISPR-Cas systems in Streptococcus thermophilus [J] . Canez Cassandra, Selle Kurt, Goh Yong Jun, FEMS Microbiology Letters . 2019,第9期

机译：在链球菌中的天然Cr CAS系统对染色体自定位的结果和表征
8. High tolerance to self-targeting of the genome by the endogenous CRISPR-Cas system in an archaeon [J] . Thorsten Allers, Uri Gophna, Anita Marchfelder, Nucleic acids research . 2017,第9期

机译：内生CRISPR-Cas系统对古细菌的基因组自我靶向具有高度耐受性
9. Quantitative proteomics of the prokaryotic immune defense system including the analysis of protein-RNA interactions within the CRISPR-Cas system [C] . Kundan Sharma, Britta Stoll, Hagen Richter, American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics . 2013

机译：原核免疫防御系统的定量蛋白质组学，包括分析CRISPR-CAS系统内的蛋白质RNA相互作用
10. The Biology of Dendritic Cells in the Context of Autoimmunity [D] . Qiu, Connie C. 2019

机译：自身免疫背景下树突细胞的生物学
11. Adaptation induced by self-targeting in a type I-B CRISPR-Cas system [O] . Aris-Edda Stachler, Julia Wörtz, Omer S. Alkhnbashi, 2020

机译：在I-B型CISCR-CAS系统中自定位引起的适应
12. SURVIVAL AND EVOLUTION OF CRISPR-CAS SYSTEM IN PROKARYOTES AND ITS APPLICATIONS [O] . Muhammad Abu Bakr Shabbir, Haihong Hao, Muhammad Zubair Shabbir, 2016

机译：原核生物CRIspR-Cas系统的存活和进化及其应用
13. Characterization and Evolution of Salmonella CRISPR-Cas Systems. [R] . Shariat, N., Timme, R. E., Pettengill, J. B., 2014

机译：沙门氏菌CRIspR-Cas系统的表征和进化。

Prokaryote autoimmunity in the context of self-targeting by CRISPR-Cas systems

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