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首页> 外文期刊>Journal of biochemical and molecular toxicology >The susceptibility to autoxidation of erythrocytes in diabetic mice: Effects of melatonin and pentoxifylline
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The susceptibility to autoxidation of erythrocytes in diabetic mice: Effects of melatonin and pentoxifylline

机译：糖尿病小鼠中红细胞自动氧化的敏感性：褪黑素和五氧化碳碱的影响

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Abstract Oxidative stress had a great importance in development of complications in diabetes. We investigated effects of melatonin and pentoxifylline in diabetic mice. Swiss albino mice ( n ?=?40) were divided into four groups: alloxan‐induced diabetes mellitus (DM), alloxan‐induced diabetes with melatonin supplementation (DM?+?MLT), alloxan‐induced diabetes with pentoxifylline supplementation (DM?+?PTX), and control. Glutathione‐peroxidase (GSH‐Px) activity, malondialdehyde (MDA) and reduced glutathione (GSH) levels, and susceptibility to oxidation of erythrocytes were measured. MDA levels were higher than control in the DM and DM?+?MLT. The DM had more MDA level than the DM?+?MLT and DM?+?PTX ( P ??0.001). After in vitro oxidation, MDA levels of all groups were found higher than the control. However, they were significantly lower than the DM in DM?+?PTX and DM?+?MLT ( P ??0.001). Although GSH levels of the DM and DM?+?PTX were less than the control, GSH‐Px activity of the DM was lower than the control and DM?+?PTX ( P ??0.05). We suggest that there is increased oxidative stress and compromised antioxidant status of erythrocytes in diabetes; however, it can be effectively prevented by melatonin or pentoxifylline supplementation.
机译：摘要氧化应激在糖尿病并发症的发生中具有重要意义。我们研究了褪黑素和己酮可可碱对糖尿病小鼠的影响。瑞士白化小鼠（n？=？40）被分为四组：四氧嘧啶诱导的糖尿病（DM）、四氧嘧啶诱导的褪黑素补充糖尿病（DM？+？MLT）、四氧嘧啶诱导的己酮可可碱补充糖尿病（DM？+？PTX）和对照组。测定谷胱甘肽过氧化物酶（GSH-Px）活性、丙二醛（MDA）和还原型谷胱甘肽（GSH）水平以及红细胞氧化敏感性。糖尿病组和糖尿病+组MDA水平均高于对照组？MLT。糖尿病组MDA水平高于糖尿病组？MLT和DM？+？PTX（P？；0.001）。体外氧化后，各组MDA水平均高于对照组。然而，在DM？+中，它们显著低于DM？PTX和DM？+？MLT（P？；0.001）。虽然DM和DM+的GSH水平？PTX低于对照组，DM的GSH-Px活性低于对照组和DM？+？PTX（P？；0.05）。我们认为糖尿病患者的红细胞氧化应激增加，抗氧化状态受损；然而，补充褪黑素或己酮可可碱可以有效预防。

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