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首页> 外文期刊>Journal of biochemical and molecular toxicology >Effect of long-term treatment with a mixture of pyrethroids on the expression of genes that govern male germ cell production in rats
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Effect of long-term treatment with a mixture of pyrethroids on the expression of genes that govern male germ cell production in rats

机译：长期处理与拟除虫菊酯混合物对大鼠雄性生殖细胞产生的基因表达的影响

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Humans are exposed to pyrethroid-based pesticides through agricultural produce. In this study, male Wistar rats were orally treated for 9 to 12 months with a mixture of pyrethroids that is equivalent to one-fifth (high dose; HD) or one-twenty fifth (low dose; LD) of the amount of pyrethroids present in the cereals and rice consumed by an average Indian. In rats treated for 9 months, the spermatogenesis-associated genes Abp, Ar, Cd9, Dax1, Dazap1, Ddx3y, Gdnf, Gfra1, Grth, Inhb, Ovol1, P1, Plzf, Pygo2, Scf, Tgfb1, Tp1, Tp2, and Vim1 were downregulated in both LD and HD groups. In rats treated for 12 months Gdnf, Hsf2, Inhb, Tgfb1, Thy1, and Ybx2 expression was downregulated in both LD and HD groups. Steroidogenesis-associated genes 17-β-Hsd, Gata4, Hmgcr, Hmgcs1, Pde4b, and Tspo gene expression were reduced in both LD- and HD-treated groups treated for 9 months. In 12-month-treated rats, Creb1 expression decreased in both LD and HD groups. The epigenetic reprogramming-associated genes, Dnmt1, Dnmt3a, Dnmt3b, Hdac10, Hplbp3, Kat3a Kat3b, Mch2ta, Ncoa7, and Sirt1 were downregulated in both HD and LD groups of 9-months-treated rats. In rats treated for 12 months, Hdac10, Mch2ta, Ncoa7, and Sirtl messenger RNA levels decreased in both the HD and LD groups. Thus, we demonstrate that long-term exposure to a mixture of pyrethroids caused aberrations in the transcriptome of factors involved in sperm production and development.
机译：人类通过农产品接触拟除虫菊酯杀虫剂。在这项研究中，雄性Wistar大鼠口服相当于五分之一（高剂量；HD）或二十五分之一（低剂量；LD）的拟除虫菊酯混合物，为期9至12个月，该混合物相当于印度人平均食用的谷物和大米中的拟除虫菊酯含量。在治疗9个月的大鼠中，LD和HD组的精子发生相关基因Abp、Ar、Cd9、Dax1、Dazap1、Ddx3y、Gdnf、Gfra1、Grth、Inhb、Ovol1、P1、Plzf、Pygo2、Scf、Tgfb1、Tp1、Tp2和Vim1均下调。在治疗12个月的大鼠中，LD组和HD组的Gdnf、Hsf2、Inhb、Tgfb1、Thy1和Ybx2表达均下调。在治疗9个月的LD和HD治疗组中，类固醇生成相关基因17-β-Hsd、Gata4、Hmgcr、Hmgcs1、Pde4b和Tspo的表达均降低。在接受12个月治疗的大鼠中，LD组和HD组的Creb1表达均降低。在9个月治疗的HD和LD组大鼠中，表观遗传重编程相关基因Dnmt1、Dnmt3a、Dnmt3b、Hdac10、Hplbp3、Kat3a Kat3b、Mch2ta、Ncoa7和Sirt1均下调。在治疗12个月的大鼠中，HD和LD组的Hdac10、Mch2ta、Ncoa7和Sirtl信使RNA水平均降低。因此，我们证明长期接触拟除虫菊酯混合物会导致精子产生和发育相关因子转录组的畸变。

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