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首页> 外文期刊>Journal of biochemical and molecular toxicology >Biosynthesized silver nanoparticles and their genotoxicity
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Biosynthesized silver nanoparticles and their genotoxicity

机译：生物合成的银纳米粒子及其遗传毒性

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The human-pathogenic bacteria have become highly resistant to conventional antibiotics; for this reason, a new biosynthesized nanomaterial might be a solution. The culture filtrate of two isolates of Fusarium oxysporum (14, 17) was used in the biosynthesis of nanosilver (AgNPs). The size of the nanoparticles produced by isolate F14 ranged from 19 to 30 nm, whereas the size of those formed via isolate F17 ranged between 16 and 25 nm. Moreover, the produced bio-nanosilver was tested against the human-pathogenic bacteria Proteus vulgaris, Escherichia coli, Staphylococcus aureus, and Klebsiella pneumonia and the outcome results displayed great antibacterial efficacy in a different manner compared with the three different biogenic antibiotics. Collectively, the results depicted that the silver nanoparticles (AgNPs) showed a three and a half times greater activity than the used antibiotics. Differential display reverse transcription-polymerase chain reaction was used to study gene regulation in the treated E. coli (F14) compared with the nontreated ones. Different upregulated and downregulated genes were observed. The cytotoxicity of the produced AgNPs was examined on rats with an average body weight of 200 g each; these animals were grouped into three different groups. The obtained AgNPs showed very low toxicity on the treated rats in comparison to the control group. The physiological parameters, for example, alanine aminotransferase, aspartate transaminase, albumin, creatinine, and urea in the treated animals were changed within to a lower degree compared with those in the nontreated animals. The current study exhibited that AgNPs might be favorable antibacterial agents, especially against multidrug-resistant bacteria.
机译：人类致病菌对常规抗生素具有高度耐药性；因此，一种新的生物合成纳米材料可能是一种解决方案。将两株尖孢镰刀菌（14,17）的培养滤液用于纳米银（AgNPs）的生物合成。分离物F14产生的纳米颗粒大小在19到30纳米之间，而通过分离物F17形成的纳米颗粒大小在16到25纳米之间。此外，对制备的生物纳米银进行了人体致病菌普通变形杆菌、大肠杆菌、金黄色葡萄球菌和肺炎克雷伯菌的测试，结果显示，与三种不同的生物抗生素相比，其在不同方式下表现出了巨大的抗菌效果。总的来说，研究结果表明，银纳米颗粒（AgNPs）的活性是使用过的抗生素的三倍半。采用差异显示反转录聚合酶链反应（Differential display reverse transcription-polymerase chain reaction）研究了经处理的大肠杆菌（F14）与未经处理的大肠杆菌（F14）的基因调控。观察到不同的上调和下调基因。在平均体重为200克的大鼠身上检测产生的AgNP的细胞毒性；这些动物被分为三组。与对照组相比，获得的AgNP对治疗组大鼠的毒性非常低。与未治疗动物相比，治疗动物体内的生理参数，例如丙氨酸转氨酶、天冬氨酸转氨酶、白蛋白、肌酐和尿素的变化程度较低。目前的研究表明，AgNPs可能是有利的抗菌剂，尤其是对多药耐药细菌。

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