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首页> 外文期刊>Journal of biochemical and molecular toxicology >Cerium oxide nanoparticles elicit antitumourigenic effect in experimental breast cancer induced by N-methyl-N- nitrosourea and benzo(a)pyrene in female Wistar rats
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Cerium oxide nanoparticles elicit antitumourigenic effect in experimental breast cancer induced by N-methyl-N- nitrosourea and benzo(a)pyrene in female Wistar rats

机译：氧化铈纳米颗粒在女性Wistar大鼠中N-甲基-N-亚硝基脲和苯并（A）芘诱导的实验乳腺癌中引发抗肿铀效应

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摘要

The use of cerium oxide nanoparticles [CeO_2NPs] in the biomedical field has continued to gain prominence due to its potent antioxidant property. This study was designed to assess the antitumorigenic effect of CeO_2NPs in rats administered N-methyl-N-nitrosourea [NMU] and benzo(a)pyrene (BaP). Twenty four female Wistar rats were equally assigned into four groups and treated with normal saline (control), [NMU + BaP], [NMU + BaP+CeO_2NPs], and [NMU + BaP +vincristine]. Animals were pretreated with NMU and BaP three times (age 7, 10, and 13 weeks). Thereafter, vincristine and CeO_2NPs were administered twice and three times per week, respectively, for 13 weeks. Results showed that the administration of NMU and BaP increased serum nitric oxide [NO] and myeloperoxidase [MPO] by 220% and 132%, respectively, whereas the activities of aspartate and alanine aminotransferases and level of total bilirubin remained unchanged. Furthermore, mammary inflammatory [NO and MPO] and oxidative stress (LPO) markers were increased by 37%, 19%, and 24%, respectively. Mammary superoxide dismutase, catalase, reduced glutathione, and glutathione-S-transferase were significantly decreased in [NMU + BaP]-administered rats by 165%, 146%, 35%, and 36%, respectively. Immunohistochemistry showed downregulation of Bax, p53, and caspase-3, while histology revealed the presence of malignant epithelial cells with pyknotic nuclei and high nucleocytoplasm in [NMU + BaP]-administered rats. Treatment with CeO_2NPs attenuated oxidative stress, apoptosis, and inflammation and restored the cytoarchitecture of the tissue. Overall, CeO_2NPs show an antitumourigenic effect in experimental breast cancer by targeting pathways linked to inflammation and apoptosis.
机译：氧化铈纳米颗粒[CeO_2NPs]由于其强大的抗氧化性能，在生物医学领域的应用继续受到重视。本研究旨在评估CeO_2NPs对服用N-甲基-N-亚硝基脲[NMU]和苯并（a）芘（BaP）的大鼠的抗肿瘤作用。24只雌性Wistar大鼠被平均分为四组，分别用生理盐水（对照组）、[NMU+BaP]、[NMU+BaP+CeO2NPs]和[NMU+BaP+长春新碱]治疗。动物用NMU和BaP预处理三次（7周、10周和13周）。此后，长春新碱和ceo2nps分别每周服用两次和三次，为期13周。结果表明，给予NMU和BaP后，血清一氧化氮[NO]和髓过氧化物酶[MPO]分别增加了220%和132%，而天冬氨酸和丙氨酸转氨酶的活性以及总胆红素水平保持不变。此外，乳腺炎症[NO和MPO]和氧化应激（LPO）标记物分别增加了37%、19%和24%。在[NMU+BaP]给药的大鼠中，乳腺超氧化物歧化酶、过氧化氢酶、还原型谷胱甘肽和谷胱甘肽-S-转移酶分别显著降低165%、146%、35%和36%。免疫组化显示Bax、p53和caspase-3表达下调，而组织学显示[NMU+BaP]给药大鼠体内存在恶性上皮细胞，细胞核固缩，核浆高。用CeO_2NPs治疗可减轻氧化应激、凋亡和炎症，并恢复组织的细胞结构。总的来说，CeO_2NPs通过靶向与炎症和凋亡相关的途径，在实验性乳腺癌中显示出抗肿瘤作用。

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