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首页> 外文期刊>Journal of biochemical and molecular toxicology >Abatement of the dysfunctional hypothalamic-pituitary-gonadal axis due to ciprof loxacin administration by selenium in male rats
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Abatement of the dysfunctional hypothalamic-pituitary-gonadal axis due to ciprof loxacin administration by selenium in male rats

机译：雄性大鼠硒的CIPROF Loxacin施用引起的功能失调丘脑 - 垂体 - 垂体轴

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The present study examined the influence of selenium on ciprofloxacin-mediated reproductive dysfunction in rats. The research design consisted of five groups of eight animals each. The rats were administered 135 mg/kg body weight of cipro-floxacin per se or simultaneously with selenium at 0.25 and 0.5 mg/kg for 15 uninterrupted days. Antioxidant and inflammatory indices were assayed using the testes, epididymis, and hypothalamus of the animals after sacrifice. Results revealed that ciprofloxacin treatment per se interfered with the reproductive axis as demonstrated by diminished serum hormonal levels, sperm quality, and enzymatic indices of testicular function, which were, however, abrogated following selenium co-treatment. Besides this, administration of selenium attenuated the depletion of glutathione level, inhibition of catalase, superoxide dismutase, glutathione-S-transferase and glutathione peroxidase activities with a concomitant reduction in reactive oxygen and nitrogen species, and lipid peroxidation in ciprofloxacin-treated in rats. Selenium treatment also mitigated ciprofloxacin-mediated elevation in nitric oxide level and of myeloperoxidase activity as well as histological lesions in the animals. Overall, selenium attenuated impairment in the male reproductive axis due to ciprofloxacin treatment through abatement of inflammation and oxidative stress in rats.
机译：本研究探讨了硒对环丙沙星介导的大鼠生殖功能障碍的影响。研究设计包括五组，每组八只动物。给大鼠服用135 mg/kg体重的环丙沙星，或同时服用0.25和0.5 mg/kg的硒，连续15天。牺牲动物后，用睾丸、附睾和下丘脑测定抗氧化和炎症指数。结果显示，环丙沙星治疗本身干扰了生殖轴，表现为血清激素水平、精子质量和睾丸功能的酶指标降低，但硒联合治疗后这些指标被取消。除此之外，在环丙沙星治疗的大鼠中，硒的施用减轻了谷胱甘肽水平的消耗、过氧化氢酶、超氧化物歧化酶、谷胱甘肽-S-转移酶和谷胱甘肽过氧化物酶活性的抑制，同时活性氧和氮物种的减少，以及脂质过氧化。硒处理还减轻了环丙沙星介导的一氧化氮水平和髓过氧化物酶活性的升高，以及动物的组织学损伤。总的来说，硒通过减轻大鼠的炎症和氧化应激减轻环丙沙星治疗对雄性生殖轴的损害。

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