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首页> 外文期刊>Journal of biochemical and molecular toxicology >Association between mitochondrial DNA content and opium exposure
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Association between mitochondrial DNA content and opium exposure

机译：线粒体DNA含量与鸦片暴露之间的关联

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To date, not much study has been done to investigate the mitochondrial DNA (mtDNA) copy number as the potential biomarker for opium exposure. Here, we conducted a cross-sectional study to determine the relative mtDNA content as the potential biomarker for opium exposure. Quantitative real-time PCR was performed to investigate the mtDNA copy number variation across 205 individuals, including blood samples of 45 opium users, 41 cigarette users, 47 dual users, and 72 never users of any product. We found a significantly higher mtDNA content among the opium-only users (adjusted OR: 3.21; 95% Cl: [1.34, 7.66]; P = .009) and dual users (adjusted OR: 2.64; 95% Cl: [1.15, 6.1]; P = .02) compared to that in never users even after adjustment for confounding factors, age, and sex. Discordantly, analysis of mitochondrial DNA in cigarette smokers revealed an indirect association between cigarette smoking and mtDNA content although it was not statistically significant. The reason behind the increased mitochondrial DNA is unclear. The possible hypothesis is that there might be a way to compensate for the oxidative damage induced by opium consumption. Taken together, our findings indicated that the mtDNA copy number may alter during opium exposure. Since changes in the mitochondrial DNA copy number was associated with the etiology of many diseases including cancer, further investigations on the mtDNA copy number may shed light on the carcinogenicity of opium consumption and means for early detection among the populations who have been exposed to opium and its products.
机译：到目前为止，还没有多少研究调查线粒体DNA（mtDNA）拷贝数作为鸦片暴露的潜在生物标志物。在这里，我们进行了一项横断面研究，以确定相对mtDNA含量作为鸦片暴露的潜在生物标志物。对205名个体进行了实时定量PCR，以调查线粒体DNA拷贝数的变化，包括45名鸦片使用者、41名香烟使用者、47名双重使用者和72名从未使用过任何产品的人的血液样本。我们发现，与从不吸食鸦片的人相比，仅吸食鸦片的人（调整后的OR:3.21；95%Cl:[1.34,7.66]；P=0.009）和双重吸食者（调整后的OR:2.64；95%Cl:[1.15,6.1]；P=0.02）的线粒体DNA含量显著高于从未吸食鸦片的人，即使在调整了混杂因素、年龄和性别后也是如此。不协调的是，对吸烟者线粒体DNA的分析揭示了吸烟与线粒体DNA含量之间的间接关联，尽管没有统计学意义。线粒体DNA增加的原因尚不清楚。可能的假设是，可能有一种方法可以补偿鸦片摄入引起的氧化损伤。综上所述，我们的研究结果表明，在鸦片暴露期间，线粒体DNA拷贝数可能会发生改变。由于线粒体DNA拷贝数的变化与包括癌症在内的许多疾病的病因有关，对线粒体DNA拷贝数的进一步研究可能有助于了解鸦片消费的致癌性，以及暴露于鸦片及其制品的人群中的早期检测方法。

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