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首页> 外文期刊>Journal of biochemical and molecular toxicology >Palbinone alleviates diabetic retinopathy in STZ-induced rats by inhibiting NLRP3 inflammatory activity
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Palbinone alleviates diabetic retinopathy in STZ-induced rats by inhibiting NLRP3 inflammatory activity

机译：通过抑制NLRP3炎性活性，捕鱼减轻了STZ诱导的大鼠的糖尿病视网膜病变

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Diabetic retinopathy (DR) is the primary cause of blindness and visual impairment in diabetes patients worldwide. However, laser and surgical therapies at DR have short-term effectiveness and cause side effects. Treatment with natural products is a reasonable alternative treatment for DR. The main objective of this investigation is to explore the efficacy of a bioactive compound such as palbinone (PB) in DR. Experimental rats were injected intraperitoneally with streptozotocin (STZ, 65 mg/kg), and these established experimental rats were treated with PB (20 mg/kg/bw) for 42 days. The observed results showed that PB considerably reduced the proinflammatory cytokine (interleukin-18 [IL-18] and IL-1β) production as well as improved the activities of antioxidant enzymes (superoxide dismutase, catalase, and glutathione peroxidase) particularly in the retinal region of STZ-induced DR rats. In addition, PB treatment improved nuclear factor ery-throid 2-related factor 2 (Nrf2) accumulation and enhanced the heme oxygenase-1 expression, and major antioxidants downregulated Nrf2 in the damaged retina. Also, the expression levels of nod-like receptor family pyrin domain containing 3 (NLRP3), cleaved-caspase-1, IL-1β, and apoptosis-associated speck-like protein containing CARD in the retinal region were notably upregulated in STZ-induced DR, which was eliminated by PB interference. PB administration exerted efficient antioxidant activities, Nrf2 pathway activation, and inhibition of NLRP3 in-flammasome. This current investigation concluded that PB considerably reduced the retinal inflammation and oxidative stress stimulated via high glucose, and also activated the antioxidative Nrf2 pathway and inhibited the NLRP3 inflammasome formation in rats.
机译：糖尿病视网膜病变（DR）是全世界糖尿病患者失明和视力受损的主要原因。然而，DR的激光和外科治疗具有短期疗效，并会引起副作用。对DR而言，使用天然产物治疗是一种合理的替代治疗方法。本研究的主要目的是探索一种生物活性化合物，如帕比龙（PB）对DR的疗效。实验大鼠腹腔注射链脲佐菌素（STZ，65 mg/kg），这些已建立的实验大鼠使用PB（20 mg/kg/bw）治疗42天。观察结果表明，铅显著减少促炎细胞因子（白细胞介素18[IL-18]和IL-1β）的产生，并提高抗氧化酶（超氧化物歧化酶、过氧化氢酶和谷胱甘肽过氧化物酶）的活性，尤其是在STZ诱导的DR大鼠的视网膜区域。此外，铅处理改善了核因子2相关因子2（Nrf2）的积累，增强了血红素加氧酶-1的表达，主要抗氧化剂下调了受损视网膜中的Nrf2。此外，在STZ诱导的DR中，视网膜区域的nod样受体家族pyrin结构域3（NLRP3）、裂解的半胱天冬酶-1、IL-1β和凋亡相关的斑点样蛋白CARD的表达水平显著上调，而铅干扰可消除这种上调。PB给药在火焰体中发挥了有效的抗氧化活性、Nrf2途径激活和NLRP3抑制作用。目前的研究表明，铅显著降低了高糖刺激的视网膜炎症和氧化应激，并激活了抗氧化Nrf2途径，抑制了大鼠NLRP3炎症小体的形成。

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