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首页> 外文期刊>Journal of biochemical and molecular toxicology >Enriched cancer stem cells, dense stroma, and cold immunity: Interrelated events in pancreatic cancer
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Enriched cancer stem cells, dense stroma, and cold immunity: Interrelated events in pancreatic cancer

机译：富含癌症干细胞，致密的基质和冷免疫：胰腺癌中的相互关联事件

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摘要

Cold tumors generally show low mutational burden and low infiltration of effector T cells. The pancreas, prostate, ovary, breast, and colon are placed into the category of cold tumors. In such tumors, effector T cells are either excluded from the tumor area or taken away from being in contact with tumor cells. The stromal reaction in the form of desmoplasia is important for the pathogenesis of tumors like the pancreas. Besides acting as a barrier for the penetration of drugs into the tumor area, the dense stroma presumably creates an immunosuppressive tumor microenviron-ment (TME), which accounts for low responses from tumor to immunotherapy. Cancer stem cells (CSCs) are an important part of the immunosuppressive complex within the TME. The presence of CSCs within the TME is related negatively to the activity of the antitumor immune system. Here, the question is how desmoplastic aggregates can influence the functionality of CSCs for promoting a cold pancreatic tumor immunity? This review is aimed at responding to this question, the disruption of which can be an effective strategy for improving responses from cold tumors to immunotherapy.
机译：冷性肿瘤通常表现出较低的突变负荷和较低的效应T细胞浸润。胰腺、前列腺、卵巢、乳腺和结肠属于冷性肿瘤。在这种肿瘤中，效应T细胞要么被排除在肿瘤区域之外，要么被从与肿瘤细胞的接触中移除。结缔组织增生形式的基质反应对胰腺等肿瘤的发病机制很重要。除了充当药物渗透到肿瘤区域的屏障外，致密的基质可能还创造了一种免疫抑制肿瘤微环境（TME），这是肿瘤对免疫治疗反应低的原因。肿瘤干细胞（CSCs）是TME内免疫抑制复合物的重要组成部分。TME内CSCs的存在与抗肿瘤免疫系统的活性呈负相关。这里的问题是，促结缔组织增生性聚集物如何影响CSCs促进胰腺肿瘤免疫的功能？这篇综述旨在回答这个问题，对其的破坏可能是改善冷肿瘤对免疫治疗反应的有效策略。

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