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首页> 外文期刊>Journal of biochemical and molecular toxicology >Q192R polymorphism in the PON1 gene and nasal polyp in a Turkish population
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Q192R polymorphism in the PON1 gene and nasal polyp in a Turkish population

机译：Q192R在土耳其人群中PON1基因和鼻息肉中的多态性

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The pathogenesis of nasal polyps is not completely understood. Oxidative damage contributes to polyp formation in the nasal mucosa. The paraoxonase 1 (PON1) enzyme is an important liver enzyme with high antioxidant activity. In this study, we investigated the correlation between Q192R genotypic polymorphism of the PON1 enzyme and nasal-polyp disease. The study examined 62 nasal-polyp patients and 88 controls. PON1 Q192R polymorphism was determined using polymerase chain reaction-restriction fragment length polymorphism. The genotype distribution of the PON1 gene was significantly different between nasal-polyp patients (QQ = 69.35%, QR =25.81%, RR = 4.83%) and healthy controls (QQ =52.27%, QR = 44.31%, RR = 3.40%). Our results suggest that the PON1 QQ genotype (odds ratio [OR] = 2.066, P = .036) is associated with a higher risk of developing the nasal-polyp disease while QR genotype (OR = 0.437, P = .021) showed a lower risk.
机译：鼻息肉的发病机制尚不完全清楚。氧化损伤有助于鼻粘膜息肉的形成。对氧磷酶1（PON1）是一种重要的肝脏酶，具有很高的抗氧化活性。在本研究中，我们调查了PON1酶Q192R基因多态性与鼻息肉疾病之间的相关性。这项研究检查了62名鼻息肉患者和88名对照者。采用聚合酶链反应限制性片段长度多态性检测PON1 Q192R多态性。PON1基因的基因型分布在鼻息肉患者（QQ=69.35%，QR=25.81%，RR=4.83%）和健康对照组（QQ=52.27%，QR=44.31%，RR=3.40%）之间存在显著差异。我们的结果表明，PON1 QQ基因型（优势比[OR]=2.066，P=0.036）与患鼻息肉病的风险较高相关，而QR基因型（OR=0.437，P=0.021）的风险较低。

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