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首页> 外文期刊>Journal of Biologically Active Products from Nature >Hepatoprotective and Nephroprotective Effects of Garcinia kola Heckel Stem Bark Extract and Triterpenoid Fraction Against Sodium Arsenite-Induced Toxicity in Rat Models
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Hepatoprotective and Nephroprotective Effects of Garcinia kola Heckel Stem Bark Extract and Triterpenoid Fraction Against Sodium Arsenite-Induced Toxicity in Rat Models

机译：胃癌Kola Heckel Hegel提取物和Triterpenoid分数对大鼠大鼠模型诱导毒性毒性

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Garcinia kola Heckel (Clusiaceae) has been widely used in ethnomedicine practice as a therapy against numerous disorders. Therefore, this study wts designed to evaluate the protective effects of orally administered G kola stem bark ethanolic extract (EEGK) and triterpenoid fraction (TFGK) against sodium arsenite-in.iuced hepatotoxicity and nephrotoxicity using rat code's for 14 days. Assays for plasma alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), totalbilirubin, urea, and creatinine, liver, kidney, and plasma superoxide dismutase (SOD), glutathione peroxidase (GPx) and reduced glutathione (GSH) activities were carried out using spectrophotoinetric methods. Gas chromatography-mass spectrometry analytical method was used to identity the bioactive compounds present in TFGK and EEGK, Hematological parameters were assayed using autoanalyzer. Data showed that TFGK reduced liver function markers viz. ALT, AST, ALP, and total bilirubin, vvhile EEGK reduced kidney function markers viz. plasma creatinine and urea. Furthermore, EEGK elevated plasma, liver and kidney SOD, GPx, and GSH while TFGK modulated hematological markers. F ladings from this study showed that TFGK substantially protected against sodium arsenite-mduced hepatotoxicity while EEGK.protected against jodium arsco ite-induced nephrotoxicity.
机译：藤黄作为一种治疗多种疾病的药物，已广泛应用于民族医学实践中。因此，本研究旨在评估口服葛根皮乙醇提取物（EEGK）和三萜组分（TFGK）对小鼠体内亚砷酸钠的保护作用。使用大鼠代码进行14天的肝毒性和肾毒性试验。采用分光光度法测定血浆丙氨酸氨基转移酶（ALT）、天冬氨酸氨基转移酶（AST）、碱性磷酸酶（ALP）、总胆红素、尿素和肌酐、肝脏、肾脏、血浆超氧化物歧化酶（SOD）、谷胱甘肽过氧化物酶（GPx）和还原型谷胱甘肽（GSH）活性。采用气相色谱-质谱分析方法鉴定TFGK和EEGK中存在的生物活性化合物，并使用自动分析仪测定血液学参数。数据显示TFGK降低了肝功能标志物，即。ALT、AST、ALP和总胆红素在EEGK期间降低肾功能指标，即。血浆肌酐和尿素。此外，EEGK可升高血浆、肝脏和肾脏SOD、GPx和GSH，而TFGK可调节血液学指标。这项研究的结果表明，TFGK对亚砷酸钠的肝毒性有显著的保护作用，而EEGK对亚砷酸钠的肝毒性有显著的保护作用。防止砷化钾引起的肾毒性。

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