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首页> 外文期刊>Journal of biomedical materials research. Part B, Applied biomaterials. >Sinus augmentation using a histone deacetylase inhibitor in a calcium sulfate carrier in rabbit: A pilot study
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Sinus augmentation using a histone deacetylase inhibitor in a calcium sulfate carrier in rabbit: A pilot study

机译：在兔硫酸钙载体中使用组蛋白脱乙酰酶抑制剂的窦增强：试验研究

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Abstract Histone deacetylase inhibitors such as sodium butyrate (SB) have been suggested to be promising candidate small molecules for bone regeneration. In this study, the capacity of SB loaded onto calcium sulfate (CaS) to enhance bone formation was investigated in a rabbit sinus model. Following preparation of the sinus access window on a randomly selected side, SB loaded onto CaS (CaS/SB) was grafted in five rabbits, and CaS alone (control) was grafted in another five rabbits. The animals were euthanized after 4 weeks for radiographic, histometric, and immunohistochemical analyses. There was a statistically significant difference in the total augmented volume between the groups in the radiographic analysis (158.22?±?39.31 mm 3 and 107.09?±?39.69 mm 3 , respectively, p ?=?0.040). The CaS/SB group showed a larger portion of mature lamellar bone and a higher level of mineralization of bone trabeculae, characterized by more intense labeling with osteocalcin compared with the control group in the immunohistochemical analysis. The number of osteocalcin‐positive cells within the central area of the augmented sinus was significantly higher in the CaS/SB group than in the control group (179?±?26.0 mm 2 and 123?±?33.2 mm 2 , respectively, p ?=?0.027). In conclusion, CaS/SB exhibited superior osteogenic potential, especially in the central portion of the augmented sinus as well as improvement of the volume maintenance for sinus augmentation. ? 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 105B: 1916–1923, 2017.
机译：摘要丁酸钠（SB）等组蛋白去乙酰化酶抑制剂被认为是骨再生的候选小分子。在本研究中，在兔窦房结模型中研究了硫酸钙（CaS）负载锑促进骨形成的能力。在随机选择一侧制备窦入路窗后，在五只兔子身上移植负载在CaS上的SB（CaS/SB），在另外五只兔子身上移植单独的CaS（对照）。4周后对动物实施安乐死，进行放射学、组织计量学和免疫组织化学分析。在放射学分析中，两组之间的总增大体积差异具有统计学意义（分别为158.22±39.31毫米3和107.09±39.69毫米3，p=0.040）。在免疫组化分析中，与对照组相比，CaS/SB组显示出更大比例的成熟板层骨和更高水平的骨小梁矿化，其特征是骨钙素标记更强烈。CaS/SB组增大窦中央区域内的骨钙素阳性细胞数量显著高于对照组（分别为179？-26.0 mm2和123？-33.2 mm2，p=0.027）。综上所述，CaS/SB具有优越的成骨潜能，尤其是在扩张窦的中央部分，并改善了扩张窦的容积维持？2016威利期刊有限公司，《生物医学材料研究》B部分：Appl Biomater，105B:1916–1923，2017年。

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