...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of biomedical materials research. Part B, Applied biomaterials. >Physico-chemical characterization and tissue healing changes by Hancornia speciosa Gomes latex biomembrane
【24h】

Physico-chemical characterization and tissue healing changes by Hancornia speciosa Gomes latex biomembrane

机译：哈康恩菊属植物胶乳胶乳胶乳胶胶生物膜的物理化学表征及组织愈合变化

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Skin wounds have been a public health concern of high frequency, in addition to requiring intensive and expensive care. The natural rubber latex (NRL) from Hancornia speciosa Gomes has been used to treat many problems in traditional medicine and also present healing properties, antifungal and anti-inflammatory activity and antinociceptive effects. The purpose of this study was to characterize the new biomembrane from the NRL of H. speciosa (HS) by Fourier transform infrared (FTIR) and mechanical strength test and to investigate its biological properties by the cytotoxicity assay and in vivo healing activity. The results showed that the HS biomembrane exhibited characteristic bands of the main component cis-1,4-polyisoprene. Besides, its Young modulus was close to human skin with adhesive-compatible mechanical characteristics. The cytotoxicity assays revealed that the HS biomembrane was not toxic to fibroblast cells neither using agar diffusion test nor MTT assay. Furthermore, the HS biomembrane stimulated the inflammatory cells and the angiogenesis, increased significantly the collagenesis and improved the quality of heal until the remodeling phase induced by implants in mice. Thus, this biomembrane has proven to be a safe and biocompatible biomaterial with healing potential, becoming an effective and low-cost alternative for the treatment of skin wounds.
机译：除了需要重症监护和昂贵的护理外，皮肤创伤一直是一个高频率的公共卫生问题。从山茱萸中提取的天然胶乳（NRL）已被用于治疗传统医学中的许多问题，并且具有愈合性能、抗真菌、抗炎活性和抗伤害作用。本研究的目的是通过傅立叶变换红外光谱（FTIR）和机械强度试验对大花蛇舌草（HS）NRL中的新生物膜进行表征，并通过细胞毒性试验和体内愈合活性研究其生物学特性。结果表明，HS生物膜的主要成分为顺-1,4-聚异戊二烯。此外，其杨氏模量接近人体皮肤，具有与粘合剂相容的力学特性。细胞毒性试验表明，无论是琼脂扩散试验还是MTT试验，HS生物膜对成纤维细胞都没有毒性。此外，HS生物膜刺激炎症细胞和血管生成，显著增加胶原生成，改善愈合质量，直至植入物诱导的小鼠重塑阶段。因此，这种生物膜已被证明是一种安全且具有愈合潜力的生物相容性生物材料，成为治疗皮肤创伤的有效且低成本的替代品。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号