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首页> 外文期刊>Journal of biomedical materials research. Part B, Applied biomaterials. >Novel genipin-collagen immobilization of polylactic acid (PLA) fibers for use as tissue engineering scaffolds
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Novel genipin-collagen immobilization of polylactic acid (PLA) fibers for use as tissue engineering scaffolds

机译：聚乳酸（PLA）纤维用作组织工程支架的新型Genipin-Collagen固定化

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摘要

The material surface plays an important role in the case of biomaterials used as tissue engineering scaffolds. On exposure to a biological environment, extra cellular matrix (ECM) proteins are adsorbed non-specifically onto the surface and cells interact indirectly with the surface through the adsorbed proteins. Most synthetic polymeric biomaterials lack the desirable surface properties for cells as well as have poor cellular adhesion due to their hydrophobic nature. The main objective of this study was to harness surface function-alization technologies to fabricate scaffolds that would be biocompatible and support the adhesion and proliferation of fibroblast cells.
机译：在用作组织工程支架的生物材料中，材料表面起着重要作用。当暴露于生物环境时，细胞外基质（ECM）蛋白质被非特异性吸附到表面，细胞通过吸附的蛋白质与表面间接相互作用。大多数合成聚合物生物材料缺乏理想的细胞表面性质，并且由于疏水性，细胞粘附性差。本研究的主要目的是利用表面功能化技术制造生物相容性支架，支持成纤维细胞的粘附和增殖。

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