...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of biomedical materials research. Part B, Applied biomaterials. >In vitro estimation of reduction in strength and wear resistance of UHMWPE for joint prostheses due to lipid-induced degradation
【24h】

In vitro estimation of reduction in strength and wear resistance of UHMWPE for joint prostheses due to lipid-induced degradation

机译：脂质引起的降解导致UHMWPE强度和耐磨性降低的体外估计

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Ultra-high molecular weight polyethylene (UHMWPE) is used as a bearing surface of joint prostheses and has been reported to absorb lipids such as squalene (SQ) and cholesterol esters in vivo. These lipids have been suggested by in vitro studies using SQ as a model lipid to have the potential to induce polymer degradation. However, the impact of lipid-induced degradation on the strength and wear resistance of UHMWPE is unknown. In this study, lipid-induced degradation was simulated by SQ absorption and subsequent accelerated aging, and its influence on the strength and wear resistance of UHMWPE was investigated using wear, fatigue crack growth, and delamination testing. Lipid-induced degradation was found to have little impact on fatigue crack growth rates and delamination resistance. These results were consistent with previous reports that lipid-induced degradation is localized near the surface. However, we also found that lipid-induced degradation increased the wear rate of both non-crosslinked and crosslinked UHMWPE by a factor of 2.5 and 14, respectively. These results indicate that lipid-induced degradation may affect the durability and long-term clinical outcome of joint replacements due to increased wear of UHMWPE.
机译：超高分子量聚乙烯（UHMWPE）被用作关节假体的支撑面，据报道在体内可吸收角鲨烯（SQ）和胆固醇酯等脂质。体外研究表明，使用SQ作为模型脂质，这些脂质具有诱导聚合物降解的潜力。然而，脂质降解对UHMWPE强度和耐磨性的影响尚不清楚。在本研究中，通过SQ吸收和随后的加速老化模拟脂质诱导的降解，并通过磨损、疲劳裂纹扩展和分层试验研究其对UHMWPE强度和耐磨性的影响。研究发现，脂质诱导的降解对疲劳裂纹扩展速率和抗分层性能几乎没有影响。这些结果与之前的报道一致，即脂质诱导的降解局限于表面附近。然而，我们还发现，脂质诱导的降解使非交联和交联UHMWPE的磨损率分别增加了2.5倍和14倍。这些结果表明，由于UHMWPE的磨损增加，脂质诱导的降解可能会影响关节置换的耐久性和长期临床结果。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号