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首页> 外文期刊>Journal of biomedical materials research. Part B, Applied biomaterials. >Development of zwitterionic sulfobetaine block copolymer conjugation strategies for reduced platelet deposition in respiratory assist devices
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Development of zwitterionic sulfobetaine block copolymer conjugation strategies for reduced platelet deposition in respiratory assist devices

机译：呼吸辅助装置中血小板沉积减少的两性离子磺基因嵌段共聚物共聚物缀合策略

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摘要

Respiratory assist devices, that utilize approximate to 2 m(2) of hollow fiber membranes (HFMs) to achieve desired gas transfer rates, have been limited in their adoption due to such blood biocompatibility limitations. This study reports two techniques for the functionalization and subsequent conjugation of zwitterionic sulfobetaine (SB) block copolymers to polymethylpentene (PMP) HFM surfaces with the intention of reducing thrombus formation in respiratory assist devices. Amine or hydroxyl functionalization of PMP HFMs (PMP-A or PMP-H) was accomplished using plasma-enhanced chemical vapor deposition. The generated functional groups were conjugated to low molecular weight SB block copolymers with N-hydroxysuccinimide ester or siloxane groups (SBNHS or SBNHSi) that were synthesized using reversible addition fragmentation chain transfer polymerization. The modified HFMs (PMP-A-SBNHS or PMP-H-SBNHSi) showed 80-95% reduction in platelet deposition from whole ovine blood, stability under the fluid shear of anticipated operating conditions, and uninhibited gas exchange performance relative to non-modified HFMs (PMP-C). Additionally, the functionalization and SBNHSi conjugation technique was shown to reduce platelet deposition on polycarbonate and poly(vinyl chloride), two other materials commonly found in extracorporeal circuits. The observed thromboresistance and stability of the SB modified surfaces, without degradation of HFM gas transfer performance, indicate that this approach is promising for longer term pre-clinical testing in respiratory assist devices and may ultimately allow for the reduction of anticoagulation levels in patients being supported for extended periods. (c) 2018 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 106B: 2681-2692, 2018.
机译：由于血液生物相容性的限制，呼吸辅助装置的使用受到了限制。呼吸辅助装置利用大约2米（2）的中空纤维膜（HFM）来实现理想的气体传输速率。本研究报告了两种将两性离子磺基甜菜碱（SB）嵌段共聚物功能化并随后共轭到聚甲基戊烯（PMP）HFM表面的技术，旨在减少呼吸辅助装置中血栓的形成。PMP-HFMs（PMP-A或PMP-H）的胺或羟基功能化是通过等离子体增强化学气相沉积实现的。生成的官能团与使用可逆加成-断裂链转移聚合合成的具有N-羟基琥珀酰亚胺酯或硅氧烷基团（SBNHS或SBNHSi）的低分子量SB嵌段共聚物共轭。改良HFMs（PMP-A-SBNHS或PMP-H-SBNHSi）显示全羊血液中血小板沉积减少80-95%，在预期操作条件下的流体剪切稳定性，以及相对于未改良HFMs（PMP-C）的不受抑制的气体交换性能。此外，功能化和SBNHSi共轭技术被证明可以减少聚碳酸酯和聚氯乙烯（在体外电路中常见的另外两种材料）上的血小板沉积。在不降低HFM气体传输性能的情况下，观察到SB修饰表面的抗血栓和稳定性，表明该方法有望用于呼吸辅助设备的长期临床前试验，并可能最终降低长期支持患者的抗凝水平。（c） 2018威利期刊有限公司《生物医学材料研究》B部分：Appl Biomater，106B:2681-26922018。

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