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首页> 外文期刊>Journal of biomedical materials research. Part B, Applied biomaterials. >Engineering a collagen matrix for cell-instructive regenerative angiogenesis
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Engineering a collagen matrix for cell-instructive regenerative angiogenesis

机译：用于工程胶原蛋白基质，用于细胞 - 指导性再生血管生成

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摘要

Engineering an angiogenic material for regenerative medicine requires knowledge of native extracellular matrix remodeling by cellular processes in angiogenesis. Vascularization remains a key challenge in the field of tissue engineering, one that can be mitigated by developing platforms conducive to guiding dynamic cell-matrix interactions required for new vessel formation. In this review, we highlight nuanced processes of angiogenesis and demonstrate how materials engineering is being used to interface with dynamic type I collagen remodeling, Notch and VEGF signaling, cell migration, and tissue morphogenesis. Because alpha 1(I)-collagen is secreted by endothelial tip cells during sprouting angiogenesis and required for migration, collagen is a very useful natural biomaterial and its angiogenic modifications are described. The balance between collagen types I and IV via secretion and degradation is tightly controlled by proteinases and other cell types that are capable of internalizing collagen to maintain tissue integrity. Thus, we provide examples in skin and cardiac tissue engineering of collagen tailoring in diverse cellular microenvironments for tissue regeneration. As our understanding of how to drive collagen remodeling and cellular phenotype through angiogenic pathways grows, our capabilities to model and manipulate material systems must continue to expand to develop novel applications for wound healing, angiogenic therapy, and regenerative medicine.
机译：为再生医学设计血管生成材料需要了解血管生成过程中的细胞外基质重塑。血管化仍然是组织工程领域的一个关键挑战，可以通过开发有利于引导新血管形成所需的动态细胞-基质相互作用的平台来缓解这一挑战。在这篇综述中，我们重点介绍了血管生成的细微过程，并展示了材料工程如何被用于与动态I型胶原重塑、Notch和VEGF信号传导、细胞迁移和组织形态发生相结合。由于α1（I）-胶原在血管生成萌芽期间由内皮尖端细胞分泌并需要迁移，因此胶原是一种非常有用的天然生物材料，并描述了其血管生成修饰。通过分泌和降解，I型和IV型胶原之间的平衡受到蛋白酶和其他能够内化胶原以维持组织完整性的细胞类型的严格控制。因此，我们在皮肤和心脏组织工程中提供了在不同的细胞微环境中裁剪胶原蛋白以促进组织再生的例子。随着我们对如何通过血管生成途径驱动胶原重塑和细胞表型的理解不断加深，我们对材料系统建模和操纵的能力必须继续扩大，以开发伤口愈合、血管生成治疗和再生医学的新应用。

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