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首页> 外文期刊>Journal of biomedical materials research. Part B, Applied biomaterials. >Effectiveness of strontium-doped brushite, bovine-derived hydroxyapatite and synthetic hydroxyapatite in rabbit sinus augmentation with simultaneous implant installation
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Effectiveness of strontium-doped brushite, bovine-derived hydroxyapatite and synthetic hydroxyapatite in rabbit sinus augmentation with simultaneous implant installation

机译:具有同声植入装置兔窦窦窦窦弥杏石和合成羟基磷灰石的有效性

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摘要

Various bone substitutes have been applied in sinus augmentation (SA) to overcome insufficient bone height at the posterior maxilla region caused by pneumatized sinus and severe alveolar bone resorption after teeth loss. However, their effectiveness in SA needs to be further elucidated. In this study, strontium-doped brushite (Sr-DCPD), a new bone substitute, together with bovine-derived hydroxyapatite (bHA) and synthetic hydroxyapatite (sHA) was used in rabbit maxillary SA with simultaneous implant installation. The sinus space-keeping capacity, resorption rate, osteoconductivity, and mechanical properties of regenerated bone, were evaluated by micro-computed tomography (CT), histological analysis, and mechanical testing. Sr-DCPD exhibited the best osteoconductivity and new bone formation (<4 weeks), but its final bone regeneration and removal torque of implants at week 12 were the lowest, mainly due to its poor space-keeping capacity and fast resorption. bHA exhibited the best space-keeping capacity and slowest resorption rate, but relative lower final bone volume and mechanical properties, while sHA showed good space-keeping capacity, slower resorption rate, and the best final bone formation and mechanical properties. sHA was most effective for SA and bHA was also an acceptable bone substitute; however, Sr-DCPD was least effective and not suitable in SA by itself.
机译:各种骨替代物已被应用于上颌窦扩大术(SA)中,以克服上颌窦气化引起的骨高度不足和牙齿缺失后严重的牙槽骨吸收。然而,它们在SA中的有效性需要进一步阐明。在本研究中,一种新型骨替代物掺锶刷石(Sr-DCPD)与牛源性羟基磷灰石(bHA)和合成羟基磷灰石(sHA)一起用于兔上颌窦房结的同时种植。通过微计算机断层扫描(CT)、组织学分析和力学测试评估窦腔保持能力、吸收率、骨传导性和再生骨的力学性能。Sr-DCPD表现出最好的骨传导性和新骨形成(<4周),但在第12周时其最终骨再生和植入物的移除扭矩最低,主要是由于其空间保持能力差和快速吸收。bHA表现出最好的空间保持能力和最慢的吸收率,但最终骨体积和力学性能相对较低,而sHA表现出良好的空间保持能力、较慢的吸收率和最佳的最终骨形成和力学性能。sHA对SA最有效,bHA也是可接受的骨替代物;然而,Sr-DCPD的效果最差,且不适合单独用于SA。

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