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首页> 外文期刊>Journal of biomedical nanotechnology >Evaluation of the Antibacterial Activity of Ag- and Au-Nanoparticles Loaded TiO2 Nanotubes
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Evaluation of the Antibacterial Activity of Ag- and Au-Nanoparticles Loaded TiO2 Nanotubes

机译：评价Ag-和Au-nanoparticle的抗菌活性加载TiO2纳米管

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Current research on the antibacterial properties of implant surfaces has focused on using titanium nanotubes (TNTs) with diameters of 100 and 200 nm, which simultaneously show the best antibacterial properties, poor osseointegration, and ability to immobilize proteins. Therefore, the research aimed to develop an implantable material based on titanium dioxide nanotubes with a diameter of 50 nm doped with silver (AgNPs) and gold nanoparticles (AuNPs), indicating good absorption and antibacterial properties. Moreover, metallic nanoparticles deposited by varying methods should maintain sphericity and lack of agglomeration. For this purpose, the surface charge, wettability, stability of nanoparticles, and antibacterial properties against Gram-positive and Gram-negative bacteria, i.e., Staphylococcus epidermidis, Streptococcus mutans, and Pseudomonas aeruginosa, were performed. Obtained results indicate a greater resistance to leaching of silver nanoparticles compared to gold nanoparticles. These results are reflected in microbiological studies, both into the time and the effectiveness of the implantable material's antibacterial activity. A greater antibacterial effect of AgNPs than AuNPs has been confirmed. Also, AgNPs inhibit the multiplication of Gram-negative bacteria to a greater extent than Gram-positive bacteria. It has been proven that the TNT platforms deposited with metal nanoparticles via the voltammetric method are more effective in deactivating microorganisms. Besides, the results have proven that smaller TNTs effectively reduce live bacteria as nanotubes with a diameter of 100 and 200 nm.
机译：目前对种植体表面抗菌性能的研究主要集中在使用直径为100和200纳米的钛纳米管（TNT），其同时显示出最好的抗菌性能、较差的骨整合性和固定蛋白质的能力。因此，本研究旨在开发一种基于二氧化钛纳米管的可植入材料，其直径为50nm，掺杂有银（AgNPs）和金纳米颗粒（AuNPs），显示出良好的吸收和抗菌性能。此外，通过不同方法沉积的金属纳米颗粒应保持球形且不结块。为此，研究了纳米颗粒的表面电荷、润湿性、稳定性以及对革兰氏阳性和革兰氏阴性细菌（即表皮葡萄球菌、变形链球菌和铜绿假单胞菌）的抗菌性能。所得结果表明，与金纳米颗粒相比，银纳米颗粒具有更强的抗浸出性。这些结果反映在微生物学研究中，包括植入材料抗菌活性的时间和有效性。AgNPs比AuNPs具有更强的抗菌作用已经得到证实。此外，AgNPs对革兰氏阴性细菌增殖的抑制程度大于革兰氏阳性细菌。已经证明，通过伏安法沉积金属纳米颗粒的TNT平台在灭活微生物方面更有效。此外，研究结果已经证明，较小的TNT可以有效地将活细菌还原为直径为100和200纳米的纳米管。

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