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首页> 外文期刊>Journal of bone and mineral research: the official journal of the American Society for Bone and Mineral Research >Skin Autofluorescence, a Noninvasive Biomarker for Advanced Glycation End-Products, Is Associated With Prevalent Vertebral and Major Osteoporotic Fractures: The Rotterdam Study
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Skin Autofluorescence, a Noninvasive Biomarker for Advanced Glycation End-Products, Is Associated With Prevalent Vertebral and Major Osteoporotic Fractures: The Rotterdam Study

机译：皮肤自发荧光，一种用于晚期糖化末端产品的非侵入性生物标志物，与普遍的椎骨和主要骨质疏松骨折相关：鹿特丹研究

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Advanced glycation end-products (AGEs), which bind to type 1 collagen in bone and skin, have been implicated in reduced bone quality. The AGE reader (TM) measures skin autofluorescence (SAF), which might be regarded as a marker of long-term accumulation of AGEs in tissues. We investigated the association of SAF with bone mineral density (BMD) and fractures in the general population. We studied 2853 individuals from the Rotterdam Study with available SAF measurements (median age, 74.1 years) and with data on prevalent major osteoporotic (MOFs: hip, humerus, wrist, clinical vertebral) and vertebral fractures (VFs: clinical + radiographic Genant's grade 2 and 3). Radiographs were assessed 4 to 5 years before SAF. Multivariate regression models were performed adjusted for age, sex, BMI, creatinine, smoking status, and presence of diabetes and additionally for BMD with interaction terms to test for effect modification. Prevalence of MOFs was 8.5% and of VFs 7%. SAF had a curvilinear association with prevalent MOFs and VFs and therefore, age-adjusted, sex stratified SAF quartiles were used. The odds ratio (OR) (95% confidence interval [CI]) of the second, third and fourth quartiles of SAF for MOFs were as follows: OR 1.60 (95% CI, 1.08-2.35;p= .02); OR 1.30 (95% CI, 0.89-1.97;p= .20), and OR 1.40 (95% CI, 0.95-2.10;p= .09), respectively, with first (lowest) quartile as reference. For VFs the ORs were as follows: OR 1.69 (95% CI, 1.08-2.64;p= .02), OR 1.74(95% CI, 1.11-2.71;p= .01), and OR 1.73 (95% CI, 1.12-2.73;p= .02) for second, third, and fourth quartiles, respectively. When comparing the top three quartiles combined with the first quartile, the OR (95% CI) for MOFs was 1.43 (95% CI, 1.04-2.00;p= .03) and for VFs was 1.72 (95% CI, 1.18-2.53;p= .005). Additional adjustment for BMD did not change the associations. In conclusion, there is evidence of presence of a threshold of skin AGEs below which there is distinctly lower prevalence of fractures. Longitudinal analyses are needed to confirm our cross-sectional findings. (c) 2020 The Authors.Journal of Bone and Mineral Researchpublished by American Society for Bone and Mineral Research.
机译：晚期糖基化终产物（AGEs）与骨和皮肤中的1型胶原结合，与骨质量降低有关。AGE reader（TM）测量皮肤自体荧光（SAF），这可能被视为组织中AGE长期累积的标志。我们调查了普通人群中SAF与骨密度（BMD）和骨折的关系。我们研究了来自鹿特丹研究的2853名个体，包括可用的SAF测量值（中位年龄74.1岁），以及流行的主要骨质疏松症（MOFs：髋关节、肱骨、手腕、临床椎体）和椎体骨折（VFs：临床+放射学Genant 2级和3级）的数据。在SAF发生前4至5年对X线片进行评估。对年龄、性别、BMI、肌酐、吸烟状况和糖尿病的存在进行多元回归模型调整，并对BMD和相互作用项进行额外调整，以测试效果修正。MOFs患病率为8.5%，VFs患病率为7%。SAF与流行的MOF和VFs呈曲线关系，因此使用了年龄调整、性别分层的SAF四分位数。MOF的SAF的第二、第三和第四个四分位数的优势比（OR）（95%置信区间[CI]）如下：OR 1.60（95%置信区间，1.08-2.35；p=0.02）；或分别为1.30（95%CI，0.89-1.97；p=0.20）和1.40（95%CI，0.95-2.10；p=0.09），以第一（最低）四分位数为参考。对于VFs，ORs如下：或1.69（95%CI，1.08-2.64；p=0.02），或1.74（95%CI，1.11-2.71；p=0.01），或1.73（95%CI，1.12-2.73；p=0.02），分别用于第二、第三和第四个四分位数。将前三个四分位数与第一个四分位数相比较时，MOFs的OR（95%CI）为1.43（95%CI，1.04-2.00；p=0.03），VFs的OR（95%CI，1.18-2.53；p=0.005）。骨密度的额外调整并没有改变这种关联。总之，有证据表明存在皮肤年龄阈值，低于该阈值，骨折发生率明显降低。需要进行纵向分析，以确认我们的横断面调查结果。（c） 2020年，作者。《骨与矿物质研究杂志》由美国骨与矿物质研究学会出版。

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