Late outcome after surgical and topical treatment for Aspergillus mediastinitis after heart transplantation

Vogt Paul R.; Aser Raed; Schmidlin Daniel; Mohacsi Paul; Berdat Pascal A.; Went Phillip; Flepp Markus; Mestres Carlos A.

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Late outcome after surgical and topical treatment for Aspergillus mediastinitis after heart transplantation

机译：手术和局部治疗后的晚期结果，心脏移植后曲霉含有血管炎

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摘要

The 7-year long-term survival after Aspergillus fumigatus mediastinitis after heart transplantation, an uncommonly described condition, is herein reported. A 66-year-old male developed an infection with A. fumigatus covering the entire thoracic cavity with a fungal turf after orthotopic heart transplantation. Repeated surgical removal of infectious and necrotic tissue together with innovative topical treatment using voriconazole and chlorhexidine combined with systemic antifungal treatment, helped in controlling the infection. Definitive wound closure was achieved by standard sternal refixation and latissimus dorsi muscle flap plasty. Survival after A. fumigatus mediastinitis after heart transplantation was achieved with sequential debridement in combination with topical application of antifungal agents.

机译：本文报告了心脏移植术后烟熏曲霉纵隔炎的7年长期存活率，这是一种罕见的情况。一名66岁男性在原位心脏移植后感染了覆盖整个胸腔的烟曲霉。反复手术切除感染和坏死组织，并使用伏立康唑和洗必泰进行创新性局部治疗，结合全身抗真菌治疗，有助于控制感染。通过标准胸骨再固定术和背阔肌肌瓣成形术，最终实现伤口闭合。心脏移植术后，通过序贯清创结合局部应用抗真菌药物，可获得烟熏曲霉纵隔炎后的存活率。

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来源
《Journal of cardiac surgery.》 |2021年第7期|共4页
作者
Vogt Paul R.; Aser Raed; Schmidlin Daniel; Mohacsi Paul; Berdat Pascal A.; Went Phillip; Flepp Markus; Mestres Carlos A.;
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作者单位

Klin Pk Dept Cardiovasc Surg Bellariastr 38 CH-8038 Zurich Switzerland;

Univ Hosp Zurich Dept Cardiovasc Surg Zurich Switzerland;

Klin Pk Dept Anaesthesia &

Intens Care Zurich Switzerland;

Klin Pk Dept Cardiol Zurich Switzerland;

Klin Pk Dept Cardiovasc Surg Bellariastr 38 CH-8038 Zurich Switzerland;

Kantonsspital Graubunden Dept Pathol Chur Switzerland;

Klin Pk Dept Infect Dis Zurich Switzerland;

Univ Hosp Zurich Dept Cardiovasc Surg Zurich Switzerland;

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原文格式 PDF
正文语种 eng
中图分类心脏血管和淋巴系外科学;
关键词
Aspergillus fumigatus; fungal infection; heart transplant; mediastinitis; mycotic aneurysm; topical treatment;

机译：曲霉菌fumigatus;真菌感染;心脏移植;纵隔炎;毒性动脉瘤;局部治疗;

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2. Neonatal surgical outcomes after prenatal diagnosis of complex congenital heart disease: experiences of a perinatal integrated diagnosis and treatment program [J] . Xu Liu, Hai-Fa Hong, Hai-Bo Zhang, 世界儿科杂志(英文版) . 2020,第005期
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机译：心脏移植患者中曲霉菌纵隔炎感染的非典型表现：联合药物治疗和外科治疗的重要性
5. Late outcomes of pediatric heart transplantation are independent of pre-transplant diagnosis and prior cardiac surgical intervention. [J] . Dionigi B, Razzouk AJ, Hasaniya NW, The Journal of heart and lung transplantation: the official publication of the International Society for Heart Transplantation . 2008,第10期

机译：小儿心脏移植的晚期结局独立于移植前的诊断和先前的心脏外科手术干预。
6. Aspergillus Mediastinitis after Orthotopic Heart Transplantation: A Case Report [J] . Magdy M. El-Sayed Ahmed MD MSc, Abdelkader Almanfi MD MRCP, Muhammad Aftab MD, Texas Heart Institute journal / . 2015,第5期

机译：原位心脏移植术后曲霉性纵隔炎：一例报告
7. A surgical robot with a heart-surface-motion synchronization mechanism for myoblast cell sheet transplantation [C] . Xu, Kangyi, Nakamura, Ryoichi Annual Conference of Japanese Society for Medical and Biological Engineering;Annual International Conference of the IEEE Engineering in Medicine and Biology Society . 2013

机译：具有心脏表面运动同步机制的成肌细胞片移植手术机器人
8. Left ventricular assist devices and bridge to transplant: Implanting earlier in the course of heart failure to improve outcomes. [D] . Pratt, Christina Mae. 2011

机译：左心室辅助设备和移植桥梁：在心力衰竭过程中尽早植入以改善预后。
9. Aspergillus Mediastinitis after Orthotopic Heart Transplantation: A Case Report [O] . Magdy M. El-Sayed Ahmed, Abdelkader Almanfi, Muhammad Aftab, 2015

机译：原位心脏移植术后曲霉性纵隔炎：一例报告
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机译：胸骨修复方法是否影响治疗纵隔炎的长期疗效

Late outcome after surgical and topical treatment for Aspergillus mediastinitis after heart transplantation

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