Translating Attention-Deficit/Hyperactivity Disorder Rating Scale-5 and Weiss Functional Impairment Rating Scale-Parent Effectiveness Scores into Clinical Global Impressions Clinical Significance Levels in Four Randomized Clinical Trials of SPN-812 (Viloxazine Extended-Release) in Children and Adolescents with Attention-Deficit/Hyperactivity Disorder

Nasser Azmi; Kosheleff Alisa R.; Hull Joseph T.; Liranso Tesfaye; Qin Peibing; Busse Gregory D.; ONeal Welton; Fava Maurizio; Faraone Stephen V.; Rubin Jonathan

首页> 外文期刊>Journal of child and adolescent psychopharmacology >Translating Attention-Deficit/Hyperactivity Disorder Rating Scale-5 and Weiss Functional Impairment Rating Scale-Parent Effectiveness Scores into Clinical Global Impressions Clinical Significance Levels in Four Randomized Clinical Trials of SPN-812 (Viloxazine Extended-Release) in Children and Adolescents with Attention-Deficit/Hyperactivity Disorder

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Translating Attention-Deficit/Hyperactivity Disorder Rating Scale-5 and Weiss Functional Impairment Rating Scale-Parent Effectiveness Scores into Clinical Global Impressions Clinical Significance Levels in Four Randomized Clinical Trials of SPN-812 (Viloxazine Extended-Release) in Children and Adolescents with Attention-Deficit/Hyperactivity Disorder

机译：翻译注意力 - 缺陷/多动障碍评级规模-5和Weiss功能损伤评级评级 - 母体有效性分数分为临床全球展示中SPN-812（Viloxaine延长）中的四种随机临床试验中的临床意义水平，儿童和青少年的注意力 - 缺陷/多动障碍

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Objectives: Clinical trials in psychiatry frequently report results from lengthy, comprehensive assessments to characterize a subject emotionally, cognitively, and behaviorally before and after treatment. However, the potential treatment implications of these results and how they translate into clinical practice remain unclear. Conversely, the Clinical Global Impressions (CGI) scales are quick, intuitive assessments used to assess the functional impact of a treatment in clinically relevant terms. The objectives of the present analyses are to translate scores from comprehensive assessments of symptom severity and functional impairment into clinically meaningful CGI levels.

机译：目的：精神病学临床试验经常报告治疗前后对受试者进行长期、全面评估的结果，以描述其情绪、认知和行为特征。然而，这些结果的潜在治疗意义以及它们如何转化为临床实践尚不清楚。相反，临床总体印象（CGI）量表是一种快速、直观的评估方法，用于从临床相关的角度评估治疗的功能影响。本分析的目的是将症状严重程度和功能损害的综合评估得分转化为具有临床意义的CGI水平。

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来源
《Journal of child and adolescent psychopharmacology》 |2021年第3期|共13页
作者
Nasser Azmi; Kosheleff Alisa R.; Hull Joseph T.; Liranso Tesfaye; Qin Peibing; Busse Gregory D.; ONeal Welton; Fava Maurizio; Faraone Stephen V.; Rubin Jonathan;
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作者单位

Supernus Pharmaceut Inc 9715 Key West Ave Rockville MD 20850 USA;

Supernus Pharmaceut Inc 9715 Key West Ave Rockville MD 20850 USA;

Supernus Pharmaceut Inc 9715 Key West Ave Rockville MD 20850 USA;

Supernus Pharmaceut Inc 9715 Key West Ave Rockville MD 20850 USA;

Supernus Pharmaceut Inc 9715 Key West Ave Rockville MD 20850 USA;

Supernus Pharmaceut Inc 9715 Key West Ave Rockville MD 20850 USA;

Supernus Pharmaceut Inc 9715 Key West Ave Rockville MD 20850 USA;

Massachusetts Gen Hosp Dept Psychiat Boston MA 02114 USA;

SUNY Upstate Med Univ Dept Psychiat Syracuse NY 13210 USA;

Supernus Pharmaceut Inc 9715 Key West Ave Rockville MD 20850 USA;

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原文格式 PDF
正文语种 eng
中图分类神经病学与精神病学;
关键词
Viloxazine Extended-Release; SPN-812; attention-deficit; hyperactivity disorder; clinical relevance; Clinical Global Impressions Scale;

机译：Viloxazine延长释放;SPN-812;注意力;多动障碍;临床相关性;临床全球印象规模;

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机译：患有注意力缺陷/多动症的儿童和青少年的Weiss功能障碍评估量表-父母报告表的心理计量学验证
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机译：患有注意力缺陷/多动症的儿童和青少年的Weiss功能障碍评估量表-父母报告表的心理计量学验证

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