Prevalence and prognostic impact of nonischemic late gadolinium enhancement in stress cardiac magnetic resonance

Grigoratos Chrysanthos; Gueli Ignazio; Arendt Christophe T.; Leithner Doris; Meloni Antonella; Nugara Cinzia; Barison Andrea; Todiere Giancarlo; Puntmann Valentina O.; Novo Giuseppina; Pepe Alessia; Emdin Michele; Nagel Eike; Aquaro Giovanni Donato

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Prevalence and prognostic impact of nonischemic late gadolinium enhancement in stress cardiac magnetic resonance

机译：非透析性晚钆增强压力心脏磁共振的患病率和预后影响

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Aim To assess the prevalence and prognostic significance of NI-LGE in patients undergoing stress-CMR. Methods Stress-CMR with either dipyridamole or adenosine was performed in 283 patients (228 men, 81%) including perfusion imaging, wall motion evaluation and LGE. Follow-up was completed in all enrolled patients (median time: 1850 days; interquartile range: 1225-2705 days). Composite endpoint included cardiac death, ventricular tachycardia, myocardial infarction, stroke, hospitalization for cardiac cause and coronary revascularization performed beyond 90 days from stress-CMR scans. Results One hundred and twelve patients (40%) had negative LGE (no-LGE), 140 patients (49%) I-LGE and 31 patients (11%) NI-LGE. Twenty-five events occurred in the no-LGE group, 68 in I-LGE and 11 in the NI-LGE group. On survival curves, patients with NI-LGE had worse prognosis than patients with no-LGE regardless of the presence of inducible perfusion defects. No significant prognostic differences were found between I-LGE and NI-LGE. Conclusion NI-LGE can be detected in 11% of patients during stress-CMR providing a diagnosis of nonischemic cardiac disease. Patients with NI-LGE have worse prognosis than those with no-LGE.

机译：目的评估压力性CMR患者中NI-LGE的患病率和预后意义。方法对283例（228名男性，81%）患者进行潘生丁或腺苷应激性CMR，包括灌注成像、室壁运动评估和LGE。所有入选患者均完成随访（中位时间：1850天；四分位区间：1225-2705天）。复合终点包括心脏死亡、室性心动过速、心肌梗死、中风、因心脏原因住院治疗，以及在压力CMR扫描后90天以上进行的冠状动脉血运重建。结果112例（40%）LGE阴性（无LGE），140例（49%）I-LGE和31例（11%）NI-LGE。无LGE组发生25起事件，I-LGE组发生68起事件，NI-LGE组发生11起事件。在生存曲线上，无论是否存在诱导性灌注缺陷，NI-LGE患者的预后都比无LGE患者差。在I-LGE和NI-LGE之间未发现显著的预后差异。结论在应激性CMR中，11%的患者可检测到NI-LGE，为非缺血性心脏病的诊断提供了依据。NI-LGE患者的预后比无LGE患者差。

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来源
《Journal of cardiovascular medicine》 |2020年第12期|共6页
作者
Grigoratos Chrysanthos; Gueli Ignazio; Arendt Christophe T.; Leithner Doris; Meloni Antonella; Nugara Cinzia; Barison Andrea; Todiere Giancarlo; Puntmann Valentina O.; Novo Giuseppina; Pepe Alessia; Emdin Michele; Nagel Eike; Aquaro Giovanni Donato;
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作者单位

Fdn Gabriele Monasterio CNR Reg Toscana Via Moruzzi 1 I-56124 Pisa Italy;

Fdn Gabriele Monasterio CNR Reg Toscana Via Moruzzi 1 I-56124 Pisa Italy;

Univ Hosp Frankfurt Inst Diagnost &

Intervent Radiol Frankfurt Germany;

Univ Hosp Frankfurt Inst Diagnost &

Intervent Radiol Frankfurt Germany;

Fdn Gabriele Monasterio CNR Reg Toscana Via Moruzzi 1 I-56124 Pisa Italy;

Fdn Gabriele Monasterio CNR Reg Toscana Via Moruzzi 1 I-56124 Pisa Italy;

Fdn Gabriele Monasterio CNR Reg Toscana Via Moruzzi 1 I-56124 Pisa Italy;

Fdn Gabriele Monasterio CNR Reg Toscana Via Moruzzi 1 I-56124 Pisa Italy;

Univ Hosp Frankfurt DZHK Ctr Cardiovasc Imaging Inst Expt &

Translat Cardiovasc Imaging;

Univ Hosp Paolo Giaccone Div Cardiol &

Cardiovasc Rehabil Dept Internal Med &

Cardiovasc Dis;

Fdn Gabriele Monasterio CNR Reg Toscana Via Moruzzi 1 I-56124 Pisa Italy;

Fdn Gabriele Monasterio CNR Reg Toscana Via Moruzzi 1 I-56124 Pisa Italy;

Univ Hosp Frankfurt DZHK Ctr Cardiovasc Imaging Inst Expt &

Translat Cardiovasc Imaging;

Fdn Gabriele Monasterio CNR Reg Toscana Via Moruzzi 1 I-56124 Pisa Italy;

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正文语种 eng
中图分类心脏、血管（循环系）疾病;
关键词
late gadolinium enhancement; nonischemic cardiac findings; nonischemic fibrosis; prognosis; stress perfusion cardiac magnetic resonance;

机译：晚期钆增强;非透析性心脏成分;非透析性纤维化;预后;应力灌注心脏磁共振;

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Prevalence and prognostic impact of nonischemic late gadolinium enhancement in stress cardiac magnetic resonance

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