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首页> 外文期刊>Journal of Biophotonics >FTIR microspectroscopy of selected rare diverse sub-variants of carcinoma of the urinary bladder
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FTIR microspectroscopy of selected rare diverse sub-variants of carcinoma of the urinary bladder

机译：泌尿膀胱癌癌的选定稀有不同亚变种的FTIR微分谱

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摘要

Urothelial carcinomas of the bladder are a heterogeneous group of tumours, although some histological sub-variants are rare and sparsely reported in the literature. Diagnosis of sub-variants from conventional urothelial carcinoma can be challenging, as they may mimic the morphology of other malignancies or benign tumours and therefore their distinction is important. For the first time, the spectral pathology of some of these sub-variants has been documented by infrared microspectroscopy and an attempt made to profile their biochemistry. It is important not only to identify and separate the cancer-associated epithelial tissue spectra from common tissue features such as stroma or blood, but also to detect the signatures of tumour sub-variants. As shown, their spectroscopic signals can change dramatically as a consequence of differentiation. Example cases are discussed and compared with histological evaluations.
机译：膀胱尿路上皮癌是一组异质性肿瘤，尽管一些组织学亚型非常罕见，文献中也鲜有报道。诊断常规尿路上皮癌的亚变异可能具有挑战性，因为它们可能模仿其他恶性肿瘤或良性肿瘤的形态，因此它们的区别很重要。红外显微光谱仪首次记录了其中一些亚变种的光谱病理学，并试图分析其生物化学特征。重要的是，不仅要从常见组织特征（如基质或血液）中识别和分离与癌症相关的上皮组织光谱，而且要检测肿瘤亚变异体的特征。如图所示，它们的光谱信号会因分化而发生显著变化。本文讨论了一些例子，并与组织学评估进行了比较。

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  • 来源
    《Journal of Biophotonics》 |2013年第1期|共15页
  • 作者

    Hughes Caryn; Iqbal-Wahid Junaid; Brown Michael; Shanks Jonathan H.; Eustace Amanda; Denley Helen; Hoskin Peter J.; West Catharine; Clarke Noel W.; Gardner Peter;

  • 作者单位

    Univ Manchester Manchester Inst Biotechnol Manchester M1 7DN Lancs England;

    Univ Manchester Translat Radiobiol Grp Inst Canc Sci Christie NHS Fdn Trust Paterson Inst Canc Res Manchester Acad Hlth Sci C Manchester M20 4BX Lancs England;

    Univ Manchester Genito Urinary Canc Res Grp Inst Canc Sci Christie NHS Fdn Trust Paterson Inst Canc Res Manchester Acad Hlth Sci C Manchester M20 4BX Lancs England;

    Christie NHS Fdn Trust Dept Histopathol Manchester M20 4BX Lancs England;

    Univ Manchester Translat Radiobiol Grp Inst Canc Sci Christie NHS Fdn Trust Paterson Inst Canc Res Manchester Acad Hlth Sci C Manchester M20 4BX Lancs England;

    Manchester Royal Infirm Cent Manchester Univ Hosp NHS Fdn Trust Manchester M13 9WL Lancs England;

    Mt Vernon Hosp Ctr Canc Northwood HA6 2RN Middx England;

    Univ Manchester Translat Radiobiol Grp Inst Canc Sci Christie NHS Fdn Trust Paterson Inst Canc Res Manchester Acad Hlth Sci C Manchester M20 4BX Lancs England;

    Univ Manchester Genito Urinary Canc Res Grp Inst Canc Sci Christie NHS Fdn Trust Paterson Inst Canc Res Manchester Acad Hlth Sci C Manchester M20 4BX Lancs England;

    Univ Manchester Manchester Inst Biotechnol Manchester M1 7DN Lancs England;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 生物物理学;
  • 关键词

    FTIR; Infrared microspectroscopy; principal component analysis; cluster analysis; support vector machines; urothelial carcinoma; transitional cell carcinoma; lipoid; clear cell;

    机译：FTIR;红外线微型光谱学;主成分分析;聚类分析;支持向量机;尿路上皮癌;过渡细胞癌;脂质;清晰的细胞;

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