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首页> 外文期刊>Journal of Biophotonics >Label-free high frame rate imaging of circulating blood clots using a dual modal ultrasound and photoacoustic system
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Label-free high frame rate imaging of circulating blood clots using a dual modal ultrasound and photoacoustic system

机译:使用双模型超声波和光声系统循环血凝块的无标记高帧速率成像

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摘要

Deep vein thrombosis (DVT) is a disorder when a blood clot (thrombus) is formed in one of the deep veins. These clots detach from the original sites and circulate in the blood stream at high velocities. Diagnosing these blood clots at an early stage is necessary to decide the treatment strategy. For label-free, in vivo, and real-time detection, high framerate photoacoustic imaging can be used. In this work, a dual modal clinical ultrasound and photoacoustic (PA) system is used for the high framerate PA imaging of circulating blood clots in blood at linear velocities up to 107 cm/sec. Blood clot had 1.4 times higher signal-to-noise ratio (SNR) in the static mode and 1.3 times higher SNR compared to blood PA signal in the flow experiments. This work demonstrates that fast-moving circulating blood clots are easy to recognize against the background PA signal and may aid in early diagnosis.
机译:深静脉血栓形成(DVT)是指在其中一条深静脉中形成血块(血栓)的疾病。这些血块从原始部位分离出来,在血液中高速循环。在早期诊断这些血栓对于决定治疗策略是必要的。对于无标记、活体和实时检测,可以使用高帧率光声成像。在这项工作中,双模式临床超声和光声(PA)系统用于以高达107厘米/秒的线速度对血液中循环血凝块进行高帧频PA成像。与血液PA信号相比,血液凝块在静态模式下的信噪比(SNR)高1.4倍,在流动实验中的信噪比(SNR)高1.3倍。这项工作表明,快速移动的循环血凝块在背景PA信号下易于识别,并可能有助于早期诊断。

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