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首页> 外文期刊>Journal of Biophotonics >Blue photobiomodulation LED therapy impacts SARS-CoV-2 by limiting its replication in Vero cells
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Blue photobiomodulation LED therapy impacts SARS-CoV-2 by limiting its replication in Vero cells

机译：通过限制VERO细胞的复制，蓝色光纤维调节LED疗法影响SARS-COV-2

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The study of any intervention able to counteract SARS-CoV-2 pandemic is considerably envisaged. It was previously shown, in in vitro models of infections, that the LED blue light is able to decrease the viral load of HSV-1 and ZIKV. In our study, LED photobiomodulation therapy (PBMT) at blue wavelengths (450, 454 and 470 nm) was tested in an in vitro model of SARS-CoV-2 infection, employing three experimental settings: SARS-CoV-2 was irradiated and then transferred to cells; already infected cells were irradiated; cells were irradiated prior to infection. A decrement of the viral load was observed when previously infected cells were irradiated with all three tested wavelengths and relevant effects were registered especially at 48 hours post-infection, possibly suggesting that the blue light could interfere with the intracellular viral replication machinery. Our in vitro findings could represent the starting point for translational applications of PBMT as a supportive approach to fight SARS-CoV-2.
机译：对任何能够对抗SARS-CoV-2大流行的干预措施的研究都是相当设想的。此前，在体外感染模型中，LED蓝光能够降低HSV-1和ZIKV的病毒载量。在我们的研究中，在SARS-CoV-2感染的体外模型中测试了蓝色波长（450、454和470 nm）的LED光生物调节疗法（PBMT），采用三种实验设置：SARS-CoV-2被照射，然后转移到细胞中；已经感染的细胞被辐射；在感染前对细胞进行辐照。当用所有三种测试波长照射先前感染的细胞时，观察到病毒载量减少，并且相关效应尤其在感染后48小时被记录，这可能表明蓝光可能干扰细胞内病毒复制机制。我们的体外研究结果可能代表了PBMT作为抗击SARS-CoV-2支持性方法的翻译应用的起点。

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