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首页> 外文期刊>Journal of Biophotonics >Detection of living cervical cancer cells by transient terahertz spectroscopy
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Detection of living cervical cancer cells by transient terahertz spectroscopy

机译：瞬态太赫兹光谱检测颈椎癌细胞

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摘要

The photonic energy of terahertz wave is in the same order of magnitude as the rotational and vibrational energy levels of organic and biological macromolecules, so it has unique advantages in detecting cells and biological macromolecules. However, in the life environment, the dynamic time scale of cell-environment interaction and structural conformation change of biological macromolecules are within picosecond to millisecond, and water has strong absorption to terahertz wave, which has become the bottleneck problem for the detection of cells and biological macromolecules by terahertz technology. In this article, we developed a set of terahertz single measurement system based on the tilt wave front of grating pulse technique. The system was employed for the terahertz detection of trace living cervical cancer cells. We achieved transient detection of the terahertz pulse time-domain waveform of the living HeLa cells. The characteristic absorption peaks were identified by Lambert-Beer law, respectively, at 0.49, 0.71, 1.04, 1.07, 1.26 and 1.37 THz. The absorbance is proportional to the cell concentration.
机译：太赫兹波的光子能量与有机和生物大分子的旋转和振动能级处于同一数量级，因此它在检测细胞和生物大分子方面具有独特的优势。然而，在生活环境中，生物大分子的细胞-环境相互作用和结构构象变化的动态时间尺度在皮秒到毫秒之间，水对太赫兹波有很强的吸收，这已成为太赫兹技术检测细胞和生物大分子的瓶颈问题。本文开发了一套基于光栅脉冲倾斜波前技术的太赫兹单次测量系统。该系统用于太赫兹检测微量活宫颈癌细胞。我们实现了活HeLa细胞太赫兹脉冲时域波形的瞬态检测。用朗伯-比尔定律分别在0.49、0.71、1.04、1.07、1.26和1.37太赫兹处确定了特征吸收峰。吸光度与细胞浓度成正比。

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  • 来源
    《Journal of Biophotonics》 |2021年第1期|共7页
  • 作者

    Shi Wei; Wang Yuezheng; Hou Lei; Ma Cheng; Yang Lei; Dong Chengang; Wang Zhiquan; Wang Haiqing; Guo Juan; Xu Shenglong; Li Jing;

  • 作者单位

    Xian Univ Technol Key Lab Ultrafast Photoelect Technol &

    Terahertz Xian 710048 Peoples R China;

    Xian Univ Technol Key Lab Ultrafast Photoelect Technol &

    Terahertz Xian 710048 Peoples R China;

    Xian Univ Technol Key Lab Ultrafast Photoelect Technol &

    Terahertz Xian 710048 Peoples R China;

    Xian Univ Technol Key Lab Ultrafast Photoelect Technol &

    Terahertz Xian 710048 Peoples R China;

    Xian Univ Technol Key Lab Ultrafast Photoelect Technol &

    Terahertz Xian 710048 Peoples R China;

    Xian Univ Technol Key Lab Ultrafast Photoelect Technol &

    Terahertz Xian 710048 Peoples R China;

    Xian Univ Technol Key Lab Ultrafast Photoelect Technol &

    Terahertz Xian 710048 Peoples R China;

    Xian Univ Technol Key Lab Ultrafast Photoelect Technol &

    Terahertz Xian 710048 Peoples R China;

    Fourth Mil Med Univ Dept Mil Prevent Med Xian Peoples R China;

    Fourth Mil Med Univ Dept Mil Prevent Med Xian Peoples R China;

    Fourth Mil Med Univ Dept Mil Prevent Med Xian Peoples R China;

  • 收录信息
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 生物物理学;
  • 关键词

    absorbance; living cervical cancer cells; terahertz time-domain spectroscopy; transient terahertz spectroscopy;

    机译：吸光度;生物宫颈癌细胞;太赫兹时域光谱;瞬态太赫兹光谱;

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