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首页> 外文期刊>Journal of Biophotonics >High-fluence light emitting diode-red light inhibits cell cycle progression in human dermal fibroblasts
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High-fluence light emitting diode-red light inhibits cell cycle progression in human dermal fibroblasts

机译：高流速发光二极管红光抑制人类皮肤成纤维细胞中的细胞周期进展

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摘要

Skin fibrosis is a debilitating feature of several systemic and dermatologic diseases. While current treatment options carry significant risk of side effects and recurrence, high-fluence light emitting diode-generated red light (LED-RL) is an alternative therapeutic that is safe, non-invasive, and accessible. We previously demonstrated LED-RL decreases fibroblast proliferation, a key pathogenic component of fibrosis. However, the cellular mechanism by which high fluence LED-RL modulates fibroblast proliferation is unclear. Herein, we explored the effects of high fluence LED-RL on human dermal fibroblast cell cycle progression. We demonstrate that LED-RL at 640 J/cm(2) induced significant arrest of cells in G(0)/G(1) compared to temperature-matched control. This was accompanied by a corresponding increase in expression of checkpoint regulator p53 in irradiated cells. These data demonstrate high fluence LED-RL may exert its anti-proliferative effect on fibroblasts by inducing G(0)/G(1) arrest. Further, this study provides insight into the molecular mechanism underlying LED-RL as an anti-fibrotic therapeutic.
机译：皮肤纤维化是几种全身性和皮肤病的一个衰弱特征。虽然目前的治疗方案存在显著的副作用和复发风险，但高通量发光二极管产生的红光（LED-RL）是一种安全、无创、易获得的替代治疗方法。我们之前已经证明，LED-RL可减少成纤维细胞增殖，这是纤维化的关键致病成分。然而，高通量LED-RL调节成纤维细胞增殖的细胞机制尚不清楚。在此，我们探讨了高通量LED-RL对人真皮成纤维细胞周期进程的影响。我们证明，与温度匹配的对照组相比，640 J/cm（2）的LED-RL在G（0）/G（1）中诱导细胞显著阻滞。这伴随着检查点调节因子p53在受照细胞中的表达相应增加。这些数据表明，高通量LED-RL可能通过诱导G（0）/G（1）阻滞对成纤维细胞发挥抗增殖作用。此外，本研究还深入了解了LED-RL作为抗纤维化治疗药物的分子机制。

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