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首页> 外文期刊>Journal of Biophotonics >In vivo sun protection factor and UVA protection factor determination using (hybrid) diffuse reflectance spectroscopy and a multi-lambda-LED light source
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In vivo sun protection factor and UVA protection factor determination using (hybrid) diffuse reflectance spectroscopy and a multi-lambda-LED light source

机译：在体内防晒系数和UVA保护因子测定中使用（混合）弥漫性反射光谱和多λ-LED光源

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摘要

The sun protection factor (SPF) values are currently determined using an invasive procedure, in which the volunteers are irradiated with ultraviolet (UV) light. Non-invasive approaches based on hybrid diffuse reflectance spectroscopy (HDRS) have shown a good correlation with conventional SPF testing. Here, we present a novel compact and adjustable DRS test system. The in vivo measurements were performed using a multi-lambda-LED light source and an 84-channel imaging spectrograph with a fiber optic probe for detection. A transmission spectrum was calculated based on the reflectance measured with sunscreen and the reflectance measured without sunscreen. The preexposure in vitro spectrum was fitted to the in vivo spectrum. Each of the 11 test products was investigated on 10 volunteers. The SPF and UVA-PF values obtained by this new approach were compared with in vivo SPF results determined by certified test institutes. A correlation coefficient R-2 = 0.86 for SPF, and R-2 = 0.92 for UVA-PF were calculated. Having examined various approaches to apply the HDRS principle, the method we present was found to produce valid and reproducible results, suggesting that the multi-lambda-LED device is suitable for in-vivo SPF testing based on the HDRS principle as well as for in-vivo UVA-PF measurements.
机译：目前，防晒系数（SPF）值是通过一种侵入性程序确定的，在该程序中，志愿者接受紫外线（UV）照射。基于混合漫反射光谱（HDRS）的非侵入性方法与传统SPF检测具有良好的相关性。在这里，我们提出了一种新型的紧凑型可调DRS测试系统。体内测量使用多λLED光源和84通道成像光谱仪进行，并使用光纤探针进行检测。根据使用防晒霜测量的反射率和不使用防晒霜测量的反射率计算透射光谱。暴露前的体外光谱与体内光谱相吻合。11种测试产品中的每一种都在10名志愿者身上进行了调查。通过这种新方法获得的SPF和UVA-PF值与认证测试机构确定的体内SPF结果进行了比较。计算了SPF的相关系数R-2=0.86，UVA-PF的相关系数R-2=0.92。在研究了应用HDRS原理的各种方法后，我们发现我们提出的方法产生了有效且可重复的结果，这表明多λLED装置适用于基于HDRS原理的体内SPF测试以及体内UVA-PF测量。

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