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首页> 外文期刊>Journal of Biophotonics >Time-gated luminescence imaging of positively chargedpoly-l-lysine-coated highly microporous silicon nanoparticles in living Hydra polyp
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Time-gated luminescence imaging of positively chargedpoly-l-lysine-coated highly microporous silicon nanoparticles in living Hydra polyp

机译：含有氢汁息肉中的带正极的阳性微孔硅纳米粒子的时间门控发光成像

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摘要

The development of non-toxic fluorescent agents alternative to heavy metal-based semiconductor quantum dots represents a relevant topic in biomedical research and in particular in the bioimaging field. Herein, highly luminescent Si-H terminal microporous silicon nanoparticles with mu s-lived photoemission are chemically modified with a two step process and successfully used as label-free probes for in vivo time-gated luminescence imaging. In this context,Hydra vulgarisis used as model organism for in vivo study and validity assessment. The application of time gating allows to pursue an effective sorting of the signals, getting rid of the most common sources of noise that are fast-decay tissue autofluorescence and excitation scattering within the tissue. Indeed, an enhancement by a factor similar to 20 in the image signal-to-noise ratio can be estimated.
机译：开发无毒荧光剂替代重金属基半导体量子点是生物医学研究，尤其是生物成像领域的一个相关课题。在此，通过两步工艺对具有mu s寿命光电发射的高发光Si-H端微孔硅纳米颗粒进行化学修饰，并成功用作体内时间门控发光成像的无标记探针。在此背景下，普通水螅被用作活体研究和有效性评估的模型生物。时间选通的应用允许对信号进行有效分类，消除最常见的噪声源，即快速衰减的组织自体荧光和组织内的激发散射。实际上，可以估计图像信噪比中类似于20的因子的增强。

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