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首页> 外文期刊>Journal of drugs in dermatology: JDD >Psychosocial Stress and Mechanisms of Skin Health: A Comprehensive Update
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Psychosocial Stress and Mechanisms of Skin Health: A Comprehensive Update

机译：心理心理压力和皮肤健康机制：全面的更新

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摘要

Although the relationship between psychosocial stress and skin health is commonly invoked in both the scientific and popular literature, its underlying mechanisms are still not well understood. In this review, we provide a comprehensive update on the pathophysiology of stress and its clinical impact on skin homeostasis. The recent characterization of a bidirectional HPA stress axis in the skin has illuminated peripheral stress pathways, with effects spanning inflammation, atopy, barrier function, dermal thinning, wound healing, and melanogenesis. Additionally, new research into the cutaneous microbiome suggests the development of stress-induced dysbiosis through the "gut-brain-skin" axis. These new findings help contextualize how lifestyle factors such as diet, personal care practices, and sleep patterns may mediate and sometimes amplify the cutaneous impacts of psychological stress. We aim to clarify these clinically important relationships and highlight areas of future study that have widespread academic, clinical, and commercial implications.
机译：虽然在科学和流行文献中都经常提到心理社会压力与皮肤健康之间的关系，但其潜在机制仍不清楚。在这篇综述中，我们全面介绍了应激的病理生理学及其对皮肤稳态的临床影响。最近对皮肤中双向HPA应力轴的描述阐明了外周应力途径，其影响跨越炎症、特应性、屏障功能、皮肤变薄、伤口愈合和黑素生成。此外，对皮肤微生物组的新研究表明，应激诱导的失调是通过“肠-脑-皮肤”轴发展的。这些新发现有助于了解生活方式因素（如饮食、个人护理实践和睡眠模式）如何介导并有时放大心理压力对皮肤的影响。我们旨在阐明这些临床上重要的关系，并强调未来研究中具有广泛学术、临床和商业意义的领域。

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