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首页> 外文期刊>Journal of cosmetic dermatology >Ultrasound assessment of tissue integration of the crosslinked hyaluronic acid filler VYC-25L in facial lower-third aesthetic treatment: A prospective multicenter study
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Ultrasound assessment of tissue integration of the crosslinked hyaluronic acid filler VYC-25L in facial lower-third aesthetic treatment: A prospective multicenter study

机译：超声评估透明质酸填料VYC-25L在面部下三分之二审美治疗中的组织 - 25L：一种潜在的多中心研究

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Background Dermal fillers have become an integral part of any aesthetic physician's intervention. Aims To assess, by means of ultrasounds, the tissue integration of the hyaluronic acid (HA) dermal filler VYC-25L in chin and jaw. Methods Prospective, noncomparative, open-label, and multicenter study conducted on healthy subjects, with age comprised between 30 and 60 years old, who attended to the clinic to perform a facial rejuvenation treatment of the lower third of the face. VYC-25L was injected using a 27G needle (supraperiosteal bolus, from 0.2 to 0.3 mL per bolus) in the chin and with canula (retrograde threads, from 0.4 to 0.6 mL) in the jaw. Ultrasound examinations (UE) were performed at each study center by the same experienced observer at baseline, immediately after injection, 48 hours, and 30 days after treatment. Results Thirty patients (10 per center) were included in the study. At baseline, UE found a characteristic heterogeneous pattern of subcutaneous cellular tissue, with alternation of soft anechoic and hyperechoic images. The UE, performed immediately after treatment, showed a poorly defined globular ultrasound pattern, with anechoic images indicative of liquid content. Forty-eight hours after treatment, UE are still showing a globular pattern, with well-defined anechoic areas. Thirty days after treatment, a thickening of the subcutaneous cellular tissue was observed in all the evaluated zones, with a total integration of the HA into the tissue. Conclusion VYC-25L might represent a significant advance in volumization/restoration of the lower face. Its biointegration was total at day 30 and practically complete at 48 hours of treatment.
机译：背景皮肤填充物已经成为任何美容医生干预的一个组成部分。目的通过超声波评估透明质酸（HA）真皮填充剂VYC-25L在下巴和下巴的组织整合。方法对30岁至60岁的健康受试者进行前瞻性、非对比性、开放性和多中心研究，这些受试者到诊所对面部下三分之一进行面部年轻化治疗。VYC-25L使用27G针头（骨膜上团注，每次0.2至0.3毫升）在下巴注射，并在下巴使用套管（逆行线注，每次0.4至0.6毫升）。在基线检查时、注射后立即、48小时和治疗后30天，由同一名经验丰富的观察者在每个研究中心进行超声检查（UE）。结果30例患者（每个中心10例）被纳入研究。在基线检查时，UE发现皮下细胞组织的特征性异质性模式，软消声图像和高回声图像交替出现。治疗后立即进行的UE显示了一种模糊的球形超声模式，消声图像显示液体含量。治疗48小时后，UE仍呈球状，有清晰的消声区域。治疗30天后，在所有评估区域观察到皮下细胞组织增厚，HA完全整合到组织中。结论VYC-25L可能代表了下面部容量化/修复的重大进展。其生物整合在第30天达到完全，在治疗48小时后几乎完成。

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