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首页> 外文期刊>Journal of Exotic Pet Medicine >Naturally occurring tetanus in a rabbit (Oryctolagus cuniculus) associated with Psoroptes cuniculi otitis
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Naturally occurring tetanus in a rabbit (Oryctolagus cuniculus) associated with Psoroptes cuniculi otitis

机译：天然存在于兔子（Oryctolagus cuniculus）中的破伤风，与psoroptes cuniculi isitis相关

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Background: Natural infection with tetanus in rabbits is not well studied, despite the fact that rabbits have been used for more than 100 years as a laboratory model of tetanus infections. Case Description: An adult male intact domestic rabbit (Oryctolagus cuniculus) was presented for lethargy and bilateral crusting with purulent discharge from the external ear canals. Cytology of the aural crusts confirmed the presence of Psoroptes cuniculi and Gram stain of the purulent material confirmed concurrent mixed bacterial otitis with a large number of nonsporulating Gram positive rods. Eight hours after presentation, the animal progressed to full body rigidity and increased respiratory effort. Tetanus was suspected based on clinical appearance, but presumptive treatment with tetanus antitoxin was declined and the patient was euthanized. Necropsy and histopathology confirmed an intact tympanum bilaterally, and no evidence of otitis media/interna or intracranial disease. Anaerobic culture of the purulent aural debris was positive for Clostridium sp. 16S rRNA gene partial sequencing on the anaerobic bacterial isolate showed 87% homology to Clostridium tetani. PCR analysis confirmed the presence of the neurotoxin gene, TetX, and the bacteria's origin as C. tetani. Western blotting and ELISA analyses did not detect free neurotoxin. Conclusions and Case Relevance: This case is unique to veterinary medicine in its confirmation of association of a C. tetani infection with Psoroptes cuniculi and otitis externa rather than associated with a penetrating injury or otitis media. Furthermore, naturally occurring tetanus in rabbits is underreported.
机译：背景：尽管兔子作为破伤风感染的实验室模型已经使用了100多年，但兔子的破伤风自然感染尚未得到很好的研究。病例描述：一只成年雄性完整家兔（Oryctolagus cuniculus）因嗜睡和双侧结痂，外耳道有脓性分泌物。耳痂细胞学检查证实存在楔状银屑病，化脓性物质的革兰氏染色证实并发混合性细菌性中耳炎和大量非多孔革兰氏阳性杆菌。在演示8小时后，该动物全身僵硬，呼吸强度增加。根据临床表现怀疑破伤风，但破伤风抗毒素的假定治疗被拒绝，患者被安乐死。尸检和组织病理学证实双侧鼓室完整，没有中耳炎/内耳炎或颅内疾病的证据。化脓性耳垢的厌氧培养对梭菌属呈阳性。厌氧细菌分离物的16S rRNA基因部分测序显示与破伤风梭菌的同源性为87%。PCR分析证实了神经毒素基因TetX的存在，以及该细菌的来源为破伤风杆菌。westernblotting和ELISA分析均未检测到游离神经毒素。结论和病例相关性：该病例是兽医学独有的，它证实了破伤风衣原体感染与楔状银屑病和外耳炎的相关性，而不是与穿透性损伤或中耳炎的相关性。此外，兔自然发生的破伤风报道不足。

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