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首页> 外文期刊>Journal of Fish Biology >Exercise-induced lordosis in zebrafish Danio rerio (Hamilton, 1822)
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Exercise-induced lordosis in zebrafish Danio rerio (Hamilton, 1822)

机译：在Zebrafish Danio Rerio（Hamilton，1822）的运动诱导雄小角病

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The anabolic effect of exercise on muscles and bones is well documented. In teleost fish, exercise has been shown to accelerate skeletogenesis, to increase bone volume, and to change the shape of vertebral bodies. Still, increased swimming has also been reported to induce malformations of the teleost vertebral column, particularly lordosis. This study examines whether zebrafish (Danio rerio) develops lordosis as a result of continuous physical exercise. Zebrafish were subjected, for 1 week, to an increased swimming exercise of 5.0, 6.5 or 8.0 total body lengths (TL) per second. Control and exercise group zebrafish were examined for the presence of vertebral abnormalities, by in vivo examination, whole mount staining for bone and cartilage and histology and micro-computed tomography (CT) scanning. Exercise zebrafish developed a significantly higher rate of lordosis in the haemal part of the vertebral column. At the end of the experiment, the frequency of lordosis in the control groups was 0.5 +/- 1.3% and that in the exercise groups was 7.5 +/- 10.6%, 47.5 +/- 10.6% and 92.5 +/- 6.0% of 5.0, 6.5 and 8.0 TL center dot s(-1), respectively. Histological analysis and CT scanning revealed abnormal vertebrae with dorsal folding of the vertebral body end plates. Possible mechanisms that trigger lordotic spine malformations are discussed. This is the first study to report a quick, reliable and welfare-compatible method of inducing skeletal abnormalities in a vertebrate model during the post-embryonic period.
机译：运动对肌肉和骨骼的合成代谢作用已有充分的文献记载。在硬骨鱼身上，运动可以加速骨骼发育，增加骨骼体积，改变椎体的形状。然而，据报道，增加游泳也会导致硬骨骨脊柱畸形，尤其是前凸。这项研究调查了斑马鱼（Danio rerio）是否因持续体育锻炼而出现前凸。对斑马鱼进行为期一周的游泳运动，增加运动量为每秒5.0、6.5或8.0条总体长（TL）。对照组和运动组斑马鱼通过活体检查、骨骼和软骨全套染色、组织学和显微计算机断层扫描（CT）检查是否存在脊椎异常。运动斑马鱼在脊柱的血液部分出现前凸的几率明显更高。实验结束时，对照组的前凸频率为0.5+/-1.3%，运动组的前凸频率分别为5.0、6.5和8.0 TL中心点s（-1）的7.5+/-10.6%、47.5+/-10.6%和92.5+/-6.0%。组织学分析和CT扫描显示椎体异常，椎体终板背折。可能的机制，触发脊柱前凸畸形进行了讨论。这是首次报道一种快速、可靠且与福利相容的方法，在胚胎后阶段在脊椎动物模型中诱导骨骼异常。

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