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首页> 外文期刊>Journal of genetics >Glutathione S-transferase P1 gene polymorphisms and susceptibility to coronary artery disease in a subgroup of north Indian population
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Glutathione S-transferase P1 gene polymorphisms and susceptibility to coronary artery disease in a subgroup of north Indian population

机译：谷胱甘肽S-转移酶P1基因多态性及对北印度人群亚组的冠状动脉疾病的易感性

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摘要

The present study aimed to investigate the association of and polymorphisms of GSTP1 with coronary artery disease (CAD) in a subgroup of north Indian population. In the present case-control study, CAD patients () and age-matched, sex-matched and ethnicity-matched healthy controls () were genotyped for polymorphisms in GSTP1 using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. Genotype distribution of and polymorphisms of GSTP1 gene was significantly different between cases and controls ( and 0.024, respectively). Binary logistic regression analysis showed significant association of A/G (odds ratio (OR): 1.6, 95% CI: 1.08-2.49, ) and G/G (OR: 3.1, 95% CI: 1.41-6.71, P 0.005) genotypes of GSTP1 , and C/T (OR: 5.8, 95% CI: 1.26-26.34, ) genotype of GSTP1 with CAD. The A/G and G/G genotypes of and C/T genotype of conferred 6.5-fold increased risk for CAD (OR: 6.5, 95% CI: 1.37-31.27, ). Moreover, the recessive model of GSTP1 is the best fit inheritance model to predict the susceptible gene effect (OR: 2.3, 95% CI: 1.11-4.92, ). In conclusion, statistically significant associations of GSTP1 (A/G, G/G) and (C/T) genotypes with CAD were observed.
机译：本研究的目的是在北印度人群的一个亚组中调查GSTP1与冠状动脉疾病（CAD）的关联和多态性。在本病例对照研究中，采用聚合酶链反应-限制性片段长度多态性（PCR-RFLP）方法对CAD患者（）和年龄匹配、性别匹配和种族匹配的健康对照（）进行GSTP1多态性基因分型。GSTP1基因的基因型分布和多态性在病例组和对照组之间存在显著差异（分别为0.024）。二元logistic回归分析显示GSTP1的A/G（优势比：1.6，95%可信区间：1.08-2.49，）和G/G（优势比：3.1，95%可信区间：1.41-6.71，P0.005）基因型和GSTP1的C/T（优势比：5.8，95%可信区间：1.26-26.34，）基因型与冠心病显著相关。的A/G和G/G基因型和C/T基因型使冠心病风险增加6.5倍（OR:6.5，95%可信区间：1.37-31.27，）。此外，GSTP1的隐性模型是预测易感基因效应的最佳遗传模型（OR:2.3，95%CI:1.11-4.92，）。总之，GSTP1（A/G，G/G）和（C/T）基因型与CAD之间存在显著的统计学相关性。

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