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首页> 外文期刊>Journal of genetics >CYP/PON genetic variations as determinant of organophosphate pesticides toxicity
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CYP/PON genetic variations as determinant of organophosphate pesticides toxicity

机译：CYP / PON遗传变异作为有机磷农药毒性的决定因素

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In the present scenario of increased accumulation of pesticides in the environment, it is important to understand its impact on human health. The focus is on gene-environment interaction, highlighting the consequences and factors that may halt the biotransformation of some pesticides and change their actual dose response curve due to mixed exposure to pesticides. The paraoxonase and cytochrome P450 gene families are involved in the metabolism of oxon derivate (toxic than its parent compound) of organophosphate pesticides, thus, mutations in these genes may impact the metabolic outcome of pesticides and subsequent health hazards. The complex multi gene-environment interaction and one gene - one risk factor are two different aspects to understand the potential health effect related to environmental exposure studies. The genetic polymorphisms are associated with varying levels of risk within the population, as gene products of varied genotype alter the biotransformation of exogenous/endogenous substrates. This paper is aimed to review the impact of endogenous and exogenous factors on a mechanistic pathway of organophosphate pesticide biotransformation and various risk associated with it among the human population. Understanding the genetic polymorphism of genes involved in pesticide metabolism and highlighting the gene isoform dependent interindividual differences to metabolize particular pesticides may help us to unravel the reasons behind differential toxicity for pesticides exposure than expected.
机译：在目前环境中农药积累增加的情况下，了解其对人类健康的影响很重要。重点是基因与环境的相互作用，强调可能阻止某些农药生物转化的后果和因素，以及由于混合接触农药而改变其实际剂量-反应曲线的因素。对氧磷酶和细胞色素P450基因家族参与有机磷农药的氧磷衍生物（比其母体化合物有毒）的代谢，因此，这些基因的突变可能会影响农药的代谢结果和随后的健康危害。复杂的多基因-环境相互作用和单基因-单风险因素是理解与环境暴露研究相关的潜在健康影响的两个不同方面。由于不同基因型的基因产物改变了外源/内源性底物的生物转化，遗传多态性与人群中不同程度的风险相关。本文旨在综述内源性和外源性因素对有机磷农药生物转化机制的影响，以及与之相关的各种风险。了解农药代谢相关基因的遗传多态性，并强调代谢特定农药的基因亚型依赖性个体间差异，可能有助于我们解开农药暴露比预期毒性差异背后的原因。

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