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首页> 外文期刊>Journal of genetics >Genomewide analysis of microsatellite markers based on sequenced database in two anuran species
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Genomewide analysis of microsatellite markers based on sequenced database in two anuran species

机译：基于氨南物种测序数据库的微卫星标志物的基因组分析

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Eukaryotic and prokaryotic cell genomes exhibit multiple microsatellites. In this study, we characterized microsatellites in genomes and genes ofNanorana parkeriandXenopus laevis.This characterization was used for gene ontology (GO) analysis of coding sequences (CDS). Compared to the genome ofN. parkeri, the genome ofX. laevisis larger and contains more number of microsatellites, but the diversity of both species are similar. Trinucleotide repeats in the genome ofN. parkeriand dinucleotide and tetranucleotide repeats in the genome ofX. laeviswere the most diverse. In both the species, diversity of microsatellites was highest in intergenic regions, followed by intron and exon regions, and lowest in coding regions. Microsatellites in CDS are thus subject to higher selective pressure. Many microsatellites are concentrated upstream and downstream of genes in both species, suggesting suppression of repeats in the middle of protein-CDS. Repeats are enriched in regions near gene termini purely due to the biophysical constraints of protein structure. In GO analysis, two and five unique GO terms, only found inN. parkeriandX. laevis, respectively, indicate advantageous mutations during species evolution. Biological process, cellular component and molecular function ontology reflected in the GO analysis predicted that the microsatellites located in CDS can alter protein function and may provide a molecular basis for species adaptation to new and changing environments.
机译：真核和原核细胞基因组显示出多个微卫星。在这项研究中，我们对非洲爪蟾基因组和基因中的微卫星进行了表征。该特征用于编码序列（CDS）的基因本体（GO）分析。与N的基因组相比。帕克里，X的基因组。laevisis更大，包含更多的微卫星，但两个物种的多样性相似。三核苷酸在N的基因组中重复。Parkerian和二核苷酸和四核苷酸在X的基因组中重复。Laevis是最多样化的。在这两个物种中，微卫星多样性在基因间区最高，其次是内含子和外显子区，在编码区最低。因此，CD中的微卫星受到更高的选择压力。在这两个物种中，许多微卫星集中在基因上游和下游，这表明在蛋白质CDS的中间抑制重复。由于蛋白质结构的生物物理限制，重复序列在靠近基因末端的区域富集。在围棋分析中，只有两个和五个独特的围棋术语被发现。帕克兰德斯。laevis分别表明了物种进化过程中的优势突变。GO分析中反映的生物过程、细胞成分和分子功能本体预测，位于CDS中的微卫星可以改变蛋白质功能，并可能为物种适应新的和变化的环境提供分子基础。

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