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首页> 外文期刊>Journal of genetics >Study on the SFRP4 gene polymorphism and expression in prostate cancer
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Study on the SFRP4 gene polymorphism and expression in prostate cancer

机译：SFRP4基因多态性及前列腺癌表达的研究

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Prostate cancer is a heterogeneous disease and considered to be the most commonly diagnosed cancer. SFRP4 gene acts as Wnt antagonist in the Wnt signalling pathway, thereby playing an important role in carcinogenesis. The aim of the present study was to investigate two single-nucleotide polymorphisms: c.958 C>A (rs1802073) and c.1019 G>A (rs1802074) in the SFRP4 gene and its expression in prostate cancer. A sample size of 100 cases and 100 age-matched controls were recruited for the study. Statistical analysis revealed the heterozygous GA genotype of rs1802074 significantly increased in cases when compared to controls. Analysis of sFRP4 expression based on the genotypes showed a significantly increased expression for the heterozygous GA and homozygous AA genotypes in cases when compared to the controls. Fold change was calculated using 2(-Delta Delta CT) method and the results showed that there were a 3.4 and 4.5 fold increase in the sFRP4 expression for GA and AA genotypes, respectively. Our results suggest that the rs1802074 polymorphism in SFRP4 gene may be associated with the risk of prostate cancer.
机译：前列腺癌是一种异质性疾病，被认为是最常见的癌症。SFRP4基因在Wnt信号通路中起Wnt拮抗剂的作用，从而在癌症发生中发挥重要作用。本研究的目的是研究SFRP4基因的两种单核苷酸多态性：c.958 c>A（rs1802073）和c.1019 G>A（rs1802074）及其在前列腺癌中的表达。本研究招募了100名病例和100名年龄匹配的对照。统计分析显示，与对照组相比，病例组rs1802074的杂合GA基因型显著增加。基于基因型的sFRP4表达分析显示，与对照组相比，病例中杂合GA和纯合AA基因型的表达显著增加。使用2（-Delta-CT）方法计算折叠变化，结果显示GA和AA基因型的sFRP4表达分别增加了3.4倍和4.5倍。我们的结果表明，SFRP4基因的rs1802074多态性可能与前列腺癌的风险有关。

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