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首页> 外文期刊>Digestive diseases >Abundance of CD163-Positive Tumor-Associated Macrophages in the Early Gastric Cancer Predicts the Recurrence after Curative Resection
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Abundance of CD163-Positive Tumor-Associated Macrophages in the Early Gastric Cancer Predicts the Recurrence after Curative Resection

机译：早期胃癌中CD163阳性肿瘤相关巨噬细胞的丰富预测治疗切除后的复发

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摘要

Background: We aimed to investigate the prognostic value of M2 macrophages to predict the recurrence of early gastric cancer (EGC). Methods: A retrospective analysis was carried out among EGC patients (95 non-recurrence and 78 recurrence) who underwent surgery at Luhe People’s Hospital of Nanjing. A 5-year recurrence status was utilized to classify the patients into the recurrence group and non-recurrence group. CD163 and proliferating cell nuclear antigen were utilized as markers to detect M2 macrophages and proliferation. Cumulative tumor recurrence curve was adopted to analyze the association between the number of tumor-associated macrophages (TAMs) and the recurrence of EGC. Colony formation and invasion abilities of MKN45 (JCRB0254, human gastric epithelial cell line) with or without M2 macrophage coculture were detected in vitro, and the xenograft model was utilized to detect in vivo effect of M2 macrophages on tumor growth. Results: The number of CD163~(+) macrophages and expression of transforming growth factor-β1, matrix metallopeptidase 9, and vascular endothelial growth factor A were significantly different between the EGC recurrence and non-recurrence group. The cumulative tumor recurrence rate was found to be dependent on the infiltration number of TAMs. M2 macrophages promoted the proliferation and invasion of human MKN45 cells in vitro, as well as tumor growth in the xenograft model. Conclusion: The abundance of CD163~(+)-positive TAMs in EGC predicts the recurrence after curative resection.
机译：背景：我们旨在研究M2巨噬细胞预测早期胃癌（EGC）复发的预后价值。方法：对南京陆河人民医院手术治疗的EGC患者（95例无复发，78例复发）进行回顾性分析。采用5年复发状态将患者分为复发组和非复发组。CD163和增殖细胞核抗原被用作检测M2巨噬细胞和增殖的标记物。采用累积肿瘤复发曲线分析肿瘤相关巨噬细胞（TAM）数量与EGC复发的关系。体外检测有无M2巨噬细胞共培养的MKN45（JCRB0254，人胃上皮细胞系）的集落形成和侵袭能力，并利用异种移植模型检测M2巨噬细胞在体内对肿瘤生长的影响。结果：EGC复发组和非复发组的CD163~（+）巨噬细胞数量、转化生长因子-β1、基质金属肽酶9和血管内皮生长因子A的表达有显著性差异。累积肿瘤复发率取决于TAM的浸润数量。M2巨噬细胞在体外促进人MKN45细胞的增殖和侵袭，以及异种移植模型中的肿瘤生长。结论：EGC中CD163~（+）-阳性TAM的丰度可预测根治性切除术后复发。

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