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首页> 外文期刊>Digestive diseases >Sarcopenia Is a New Risk Factor of Nonalcoholic Fatty Liver Disease in Patients with Inflammatory Bowel Disease
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Sarcopenia Is a New Risk Factor of Nonalcoholic Fatty Liver Disease in Patients with Inflammatory Bowel Disease

机译：嗜血症患者炎症性肠病患者是非酒精性脂肪肝病的新风险因素

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Background and Aim: Recently, sarcopenia has been proposed as an additional risk factor of nonalcoholic fatty liver disease (NAFLD), and there have been no studies in patients with inflammatory bowel disease (IBD). We aimed to analyze the clinical associations between sarcopenia and NAFLD in IBD patients. Methods: From January 2004 to December 2017, a total of 488 IBD patients, with CT results, were classified according to the presence of NAFLD. Sarcopenia was assessed based on the muscle volume calculated by the total psoas muscle area in the third lumbar region divided by the square of the patient’s height (m~(2)). Results: Among the 443 included patients, NAFLD was diagnosed in 49 patients (11.1%). Sarcopenia was noted in 34.9%; it was more common in the NAFLD group (51.0 vs. 33.0%; p = 0.019). In multivariate analysis, metabolic syndrome (odds ratio [OR], 8.63), hyperuricemia (OR, 4.66), small bowel resection (OR, 3.45), and sarcopenia (OR, 2.99) were significant risk factors of NAFLD in IBD patients. In addition, sarcopenia was an independent risk factor after adjustment for age, sex, and other metabolic factors (OR, 2.26). Conclusions: The prevalence of nonalcoholic fatty liver in IBD patients was 11.1%, and sarcopenia was an independent risk factor.
机译：背景与目的：最近，肌细胞减少症被认为是非酒精性脂肪性肝病（NAFLD）的一个额外危险因素，但还没有针对炎症性肠病（IBD）患者的研究。我们旨在分析IBD患者中肌细胞减少症和NAFLD之间的临床相关性。方法：从2004年1月到2017年12月，共有488例IBD患者根据NAFLD的存在进行了分类，并进行了CT检查。根据第三腰椎区域腰大肌总面积除以患者身高（m2）的平方计算的肌肉体积来评估肌肉减少症。结果：443例患者中，49例（11.1%）诊断为NAFLD。肌肉减少症占34.9%；NAFLD组更常见（51.0比33.0%；p=0.019）。在多变量分析中，代谢综合征（优势比[OR]，8.63）、高尿酸血症（OR，4.66）、小肠切除术（OR，3.45）和肌肉减少症（OR，2.99）是IBD患者NAFLD的重要危险因素。此外，在调整了年龄、性别和其他代谢因素后，肌肉减少症是一个独立的风险因素（OR，2.26）。结论：IBD患者中非酒精性脂肪肝的患病率为11.1%，肌肉减少症是一个独立的危险因素。

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