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Quaternary ammonium isobaric tag for a relative and absolute quantification of peptides

机译：季铵同学标签用于肽的相对和绝对量化

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Abstract >Isobaric labeling quantification of peptides has become a method of choice for mass spectrometry‐based proteomics studies. However, despite of wide variety of commercially available isobaric tags, none of the currently available methods offers significant improvement of sensitivity of detection during MS experiment. Recently, many strategies were applied to increase the ionization efficiency of peptides involving chemical modifications introducing quaternary ammonium fixed charge. Here, we present a novel quaternary ammonium–based isobaric tag for relative and absolute quantification of peptides (QAS‐iTRAQ 2‐plex). Upon collisional activation, the new stable benzylic‐type cationic reporter ion is liberated from the tag. Deuterium atoms were used to offset the differential masses of a reporter group. We tested the applicability of QAS‐iTRAQ 2‐plex reagent on a series of model peptides as well as bovine serum albumin tryptic digest. Obtained results suggest usefulness of this isobaric ionization tag for relative and absolute quantification of peptides. </abstract> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> <div class="translation abstracttxt"> <span class="zhankaihshouqi fivelineshidden" id="abstract"> <span>机译：</span><abstract xmlns=”http://www.wiley.com/namespaces/wiley“type=“main”xml:lang=“en”><title type=“main”“>摘要>肽的等压标记定量已成为基于质谱的蛋白质组学研究的首选方法。然而，尽管市面上有各种各样的等压标记，但目前可用的方法都不能显著提高MS实验中的检测灵敏度。最近，许多策略被用于提高通过引入季铵固定电荷进行化学修饰的肽的电离效率。在这里，我们提出了一种新的基于季铵盐的等压标签，用于肽的相对和绝对定量（QAS-iTRAQ 2-plex）。碰撞活化后，新的稳定苄基型阳离子报告离子从tag中释放出来。氘原子被用来抵消报告基团的不同质量。我们测试了QAS-iTRAQ 2-复合试剂对一系列模型肽以及牛血清白蛋白胰蛋白酶消化物的适用性。获得的结果表明，这种等压电离标签对于肽的相对和绝对定量是有用的 </abstract> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> </div> <div class="record"> <h2 class="all_title" id="enpatent33" >著录项</h2> <ul> <li> <span class="lefttit">来源</span> <div style="width: 86%;vertical-align: text-top;display: inline-block;"> <a href='/journal-foreign-34906/'>《Journal of mass spectrometry: JMS》</a> <b style="margin: 0 2px;">|</b><span>2018年第2期</span><b style="margin: 0 2px;">|</b><span>共9页</span> </div> </li> <li> <div class="author"> <span class="lefttit">作者</span> <p id="fAuthorthree" class="threelineshidden zhankaihshouqi"> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Setner Bartosz&option=202" target="_blank" rel="nofollow">Setner Bartosz;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Stefanowicz Piotr&option=202" target="_blank" rel="nofollow">Stefanowicz Piotr;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Szewczuk Zbigniew&option=202" target="_blank" rel="nofollow">Szewczuk Zbigniew;</a> </p> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zkzz" style="display: none;">展开▼</span> </div> </li> <li> <div style="display: flex;"> <span class="lefttit">作者单位</span> <div style="position: relative;margin-left: 3px;max-width: 639px;"> <div class="threelineshidden zhankaihshouqi" id="fOrgthree"> <p>Faculty of ChemistryUniversity of Wroc?awF. Joliot‐Curie 14 Wroc?aw 50‐383 Poland;</p> <p>Faculty of ChemistryUniversity of Wroc?awF. Joliot‐Curie 14 Wroc?aw 50‐383 Poland;</p> <p>Faculty of ChemistryUniversity of Wroc?awF. Joliot‐Curie 14 Wroc?aw 50‐383 Poland;</p> </div> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zhdw" style="display: none;">展开▼</span> </div> </div> </li> <li > <span class="lefttit">收录信息</span> <span style="width: 86%;vertical-align: text-top;display: inline-block;"></span> </li> <li> <span class="lefttit">原文格式</span> <span>PDF</span> </li> <li> <span class="lefttit">正文语种</span> <span>eng</span> </li> <li> <span class="lefttit">中图分类</span> <span><a href="https://www.zhangqiaokeyan.com/clc/1187.html" title="分析化学">分析化学;</a></span> </li> <li class="antistop"> <span class="lefttit">关键词</span> <p style="width: 86%;vertical-align: text-top;"> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=derivatization of peptides&option=203" rel="nofollow">derivatization of peptides;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=isobaric tags&option=203" rel="nofollow">isobaric tags;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=peptide sequencing&option=203" rel="nofollow">peptide sequencing;</a> </p> <div class="translation"> 机译：None; </div> </li> </ul> </div> </div> <div class="literature cardcommon"> <div class="similarity "> <h3 class="all_title" id="enpatent66">相似文献</h3> <div class="similaritytab clearfix"> <ul> <li class="active" >外文文献</li> <li >中文文献</li> <li >专利</li> </ul> </div> <div class="similarity_details"> <ul > <li> <div> <b>1. </b><a class="enjiyixqcontent" href="/academic-journal-cn_journal-integrative-plant-biology_thesis/0201273481711.html">Isobaric Tags for Relative and Absolute Quantification-based Comparative Proteomics Reveals the Features of Plasma Membrane-Associated Proteomes of Pollen Grains and Pollen Tubes from Lilium davidii</a> <b>[J]</b> . <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Bing Han&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Bing Han,</a> <a 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HU Da-wei</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=CHEN Jian-min&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,CHEN Jian-min</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=YE Xing-nan&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,YE Xing-nan</a> <span> <a href="/conference-cn-9099/" target="_blank" rel="nofollow" class="tuijian_authcolor"> . 第五届全国博士生会议暨环境科学与工程新理论、新技术学术研讨会 </a> <span> <span> . 2011</span> </span> </div> </li> <li> <div> <b>2. </b><a class="enjiyixqcontent" href="/academic-degree-domestic_mphd_thesis/020313157234.html">MRI quantification of Hepatic and pancreatic fat content in First Degree relatives of Type 2 Diabetics.</a> <b>[A] </b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Guduru Harsha&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . Guduru Harsha</a> <span> . 2012</span> </span> </div> </li> </ul> <ul style="display: none;"> <li> <div> <b>1. </b><a class="enjiyixqcontent" href="/patent-detail/06130404313829.html">Quaternary ammonium containing isobaric tag for quantitative glycan profiling</a> <b>[P]</b> . <span> 外国专利：  US10254291B2 </span> <span> . 2019-04-09</span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：含季铵盐的同量异位标记，用于定量分析聚糖 </span> </p> </li> <li> <div> <b>2. </b><a class="enjiyixqcontent" href="/patent-detail/06130408567716.html">METHOD AND SYSTEM FOR IDENTIFICATION AND QUANTIFICATION OF PEPTIDE CONSIDERING NOISE OF QUANTITATIVE MASS SPECTROMETRY ANALYSIS BASED ON ISOBARIC TAG</a> <b>[P]</b> . <span> 外国专利：  KR101768098B1 </span> <span> . 2017-08-16</span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：基于等量标记的定量质谱分析噪声的多肽鉴定和定量方法及系统 </span> </p> </li> <li> <div> <b>3. </b><a class="enjiyixqcontent" href="/patent-detail/06130411470837.html">METHOD AND SYSTEM FOR IDENTIFICATION AND QUANTIFICATION OF PEPTIDE CONSIDERING NOISE OF QUANTITATIVE MASS SPECTROMETRY ANALYSIS BASED ON ISOBARIC TAG</a> <b>[P]</b> . <span> 外国专利：  KR20160086197A </span> <span> . 2016-07-19</span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：基于等量标记的定量质谱分析噪声的多肽鉴定和定量方法及系统 </span> </p> </li> </ul> </div> </div> </div> <div class="theme cardcommon" style="overflow: auto;display:none"> <h3 class="all_title" id="enpatent55">相关主题</h3> <ul id="subject"> </ul> </div> </div> </div> </div> <div class="right rightcon"> <div class="details_img cardcommon clearfix" style="margin-bottom: 10px;display:none;" > </div> </div> </div> <div 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