> Platycodon grandiflorum (PG) is extensively used for treating c'/> Rapid characterization of chemical constituents of <fc xmlns='http://www.wiley.com/namespaces/wiley'> <fi>Platycodon grandiflorum</fi> </fc> <fi xmlns='http://www.wiley.com/namespaces/wiley'>Platycodon grandiflorum</fi>Platycodon grandiflorum and its adulterant <i xmlns='http://www.wiley.com/namespaces/wiley'>Adenophora strictaAdenophora stricta by UPLC‐QTOF‐MS/MS
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首页> 外文期刊>Journal of mass spectrometry: JMS >Rapid characterization of chemical constituents of Platycodon grandiflorum Platycodon grandiflorumPlatycodon grandiflorum and its adulterant Adenophora strictaAdenophora stricta by UPLC‐QTOF‐MS/MS
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Rapid characterization of chemical constituents of Platycodon grandiflorum Platycodon grandiflorumPlatycodon grandiflorum and its adulterant Adenophora strictaAdenophora stricta by UPLC‐QTOF‐MS/MS

机译：快速表征 platycodon grandiflorum platycodon grandiflorum及其惯例 adenophora stricta adenophora stricta by Uplc -qtof-ms / ms

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摘要

> Platycodon grandiflorum (PG) is extensively used for treating cough, excessive phlegm, sore throat, bronchitis and asthma, whereas Adenophora stricta (AS) is commonly used to reduce phlegm, clear lung and tonify stomach. Due to similar appearances, PG is sometimes adulterated with cheap AS so as to gain profits. And this will inevitably result in different pharmacological property. In order to further clarify the differences in the chemical composition of these two Chinese herbs, the ultra‐high performance liquid chromatography combined with quadrupole time‐of‐flight tandem mass spectrometry coupled with UNIFI platform was used to establish a reliable, simple, sensitive and rapid analytical method. Seventy‐five compounds, including triterpenoid saponins, organic acids, flavonoids, steroids, phenols, etc., were identified from PG based on MS E data and retention time under the optimized conditions. Meanwhile, 57 compounds including triterpenoid saponins, organic acids, steroids, phenols, alkaloids, etc. were identified from AS. Among all the identified compounds, there were only 14 common components (mainly organic acids) existing in two herbs, and most of the other chemical compositions are totally different between the two herbs. Based on the results, AS cannot substitute for PG. In addition, PG adulterated with AS will lead a poor efficacy in clinical application. In addition, the systematic comparison of similarities and differences between two Chinese herbs will provide reliable characterization profiles to clarify the pharmacological fundamental substances.
机译：>桔梗（PG）广泛用于治疗咳嗽、痰过多、喉咙痛、支气管炎和哮喘，而紫茎泽兰（AS）常用于化痰、清肺、健胃。由于类似的外观，PG有时会掺杂廉价商品以获取利润。这将不可避免地导致不同的药理特性。为了进一步阐明这两种中草药化学成分的差异，采用超高效液相色谱结合四极杆飞行时间串联质谱，结合UNIFI平台，建立了一种可靠、简便、灵敏、快速的分析方法。根据MSE数据和优化条件下的保留时间，从PG中鉴定出75种化合物，包括三萜皂苷、有机酸、黄酮类、甾体、酚类等。同时，从AS中鉴定出57种化合物，包括三萜皂苷、有机酸、甾体、酚类、生物碱等。在所有已鉴定的化合物中，只有14种常见成分（主要是有机酸）存在于两种草药中，并且两种草药之间的大多数其他化学成分完全不同。从结果来看，AS不能替代PG。此外，掺有AS的PG在临床应用中会导致不良疗效。此外，系统比较两种中草药之间的相似性和差异，将提供可靠的特征描述，以阐明药理基础物质

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  • 来源
    《Journal of mass spectrometry: JMS》 |2017年第10期|共14页
  • 作者

    Wang Cuizhu; Zhang Nanqi; Wang Zhenzhou; Qi Zeng; Zheng Bingzhen; Li Pingya; Liu Jinping;

  • 作者单位

    Research Center of Natural Drug School of Pharmaceutical SciencesJilin UniversityFujin Road 1266 Changchun 130021 China;

    Research Center of Natural Drug School of Pharmaceutical SciencesJilin UniversityFujin Road 1266 Changchun 130021 China;

    Research Center of Natural Drug School of Pharmaceutical SciencesJilin UniversityFujin Road 1266 Changchun 130021 China;

    Research Center of Natural Drug School of Pharmaceutical SciencesJilin UniversityFujin Road 1266 Changchun 130021 China;

    Research Center of Natural Drug School of Pharmaceutical SciencesJilin UniversityFujin Road 1266 Changchun 130021 China;

    Research Center of Natural Drug School of Pharmaceutical SciencesJilin UniversityFujin Road 1266 Changchun 130021 China;

    Research Center of Natural Drug School of Pharmaceutical SciencesJilin UniversityFujin Road 1266 Changchun 130021 China;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 分析化学;
  • 关键词

    Adenophora stricta; chemical constituents; Platycodon grandiflorum; UNIFI platform; UPLC‐QTOF‐MS/MS;

    机译：None;

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