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首页> 外文期刊>Journal of mass spectrometry: JMS >Untargeted analysis of pure snail slime and snail slime-induced Au nanoparticles metabolome with MALDI FT-ICR MS
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Untargeted analysis of pure snail slime and snail slime-induced Au nanoparticles metabolome with MALDI FT-ICR MS

机译：对纯蜗牛粘液和蜗牛粘液诱导的Au纳米粒子代谢与Maldi FT-ICR MS的未确定分析

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Chronic wounds result from the failure of the normal wound healing process. Any delay during the tissue repair process could be defined as chronic wound healing, potentially having a highly detrimental impact on human health. To face this problem, in the last years, the use of different technologies alternative to therapeutic agents is gaining more attention. The Helix aspersa snail slime-based products are increasingly being used for skin injury, thanks to their ability to make tissue repair processes faster. To date, a comprehensive overview of pure snail slime metabolome is not available. Besides, Au nanoparticles (AuNPs) technology is spreading rapidly in the medical environment, and the search for AuNPs "green" synthetic routes that involve natural products as precursor agents is demanded, alongside with a deep comprehension of the kind of species that actively take part in synthesis and product stabilization. The aim of this work is to characterize the metabolic profile of a pure snail slime sample, by an untargeted high-resolution mass spectrometry-based analysis. In addition, insights on AuNPs synthesis and stabilization by the main components of pure snail slime used to induce the synthesis were obtained. The untargeted analysis provided a large list of important classes of metabolites, that is, fatty acid derivatives, amino acids and peptides, carbohydrates and polyphenolic compounds that could be appreciated in both samples of slime, with and without AuNPs. Moreover, a direct comparison of the obtained results suggests that mostly nitrogen and sulfur-bearing metabolites take part in the synthesis and stabilization of AuNPs.
机译：慢性伤口是正常伤口愈合过程失败的结果。组织修复过程中的任何延迟都可以被定义为慢性伤口愈合，可能会对人类健康产生非常有害的影响。为了解决这个问题，在过去的几年里，使用不同的技术替代治疗药物正受到越来越多的关注。由于能够加快组织修复过程，基于蜗牛黏液的产品越来越多地用于皮肤损伤。到目前为止，还没有关于纯蜗牛粘液代谢组的全面概述。此外，金纳米颗粒（AuNPs）技术正在医疗环境中迅速普及，需要寻找以天然产物为前体剂的AuNPs“绿色”合成路线，同时深入了解积极参与合成和产品稳定的物种。这项工作的目的是通过无目标的高分辨率质谱分析来表征纯蜗牛黏液样本的代谢特征。此外，还获得了用于诱导合成的纯蜗牛粘液的主要成分对AuNPs合成和稳定性的见解。非目标分析提供了大量重要类别的代谢物，即脂肪酸衍生物、氨基酸和肽、碳水化合物和多酚化合物，在含有和不含AUNP的两种黏液样品中都可以看到这些代谢物。此外，对所得结果的直接比较表明，大多数含氮和含硫代谢物参与了AuNP的合成和稳定。

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