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首页> 外文期刊>Journal of mass spectrometry: JMS >Cannabis and its cannabinoids analysis by gas chromatography-mass spectrometry with Cold EI
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Cannabis and its cannabinoids analysis by gas chromatography-mass spectrometry with Cold EI

机译：用冷EI气相色谱 - 质谱分析大麻及其大麻素分析

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Cannabis extracts and products were analyzed by gas chromatography-mass spectrometry (GC-MS) with Cold EI for their full content including terpenes, sesquiterpenes, sesquiterpinols, fatty acids, delta 9-tetrahydrocannabinol (THC), cannabidiol (CBD), other cannabinoids, hydrocarbons, sterols, diglycerides, triglycerides, and impurities. GC-MS with Cold EI is based on interfacing GC and MS with supersonic molecular beams (SMB) along with electron ionization of vibrationally cold sample compounds in the SMB in a fly-through ion source (hence the name Cold EI). GC-MS with Cold EI improves all the performance aspects of GC-MS, enables the analysis of Cannabinoids with OH groups without derivatization, while providing enhanced molecular ions for improved identification, and enables internal quantitation without calibration. We found over 50 cannabinoid compounds including a new one with a Cold EI mass spectrum very similar to delta 9-THC as well as relatively large cannabinoids with molecular weight above m/z = 400. Because the analysis was universal in full scan and not targeted, we found impurities such as bromo CBD and fluticasone propionate and could monitor the formation of oxidized CBD during decarboxylation. In addition, GC-MS with Cold EI enabled nontargeted full analysis of terpenes, sesquiterpenes, and sesquiterpinols in cannabis extracts with good internal quantitation. GC-MS with Cold EI further served with very good sensitivity for the concentration determination of delta 9-THC in CBD-related products. Finally, cannabis drugs such as EP-1 used in Israel for treatment of epilepsy and for children with autism spectrum disorder (ASD) were analyzed for their full cannabinoids content for learning on the entourage effect and for drug activity optimization.
机译：通过气相色谱-质谱（GC-MS）和冷EI分析大麻提取物和产品的全部含量，包括萜烯、倍半萜、倍半萜、脂肪酸、δ9-四氢大麻酚（THC）、大麻素（CBD）、其他大麻素、碳氢化合物、甾醇、甘油三酯、甘油三酯和杂质。带有冷EI的GC-MS基于将GC和MS与超音速分子束（SMB）连接，以及在飞越离子源（因此得名冷EI）中SMB中振动冷样品化合物的电子电离。带有冷EI的GC-MS改进了GC-MS的所有性能方面，能够在不进行衍生化的情况下分析带有OH基团的大麻素，同时提供增强的分子离子以改进鉴定，并且能够在无需校准的情况下进行内部定量。我们发现了50多种大麻素化合物，包括一种新的具有与δ9-THC非常相似的冷EI质谱的大麻素，以及分子量大于m/z=400的相对较大的大麻素。由于该分析在全扫描中是通用的，并且没有针对性，我们发现了溴代CBD和丙酸氟替卡松等杂质，并且可以监测脱羧过程中氧化CBD的形成。此外，使用冷EI的GC-MS能够对大麻提取物中的萜烯、倍半萜和倍半萜进行非目标全面分析，并具有良好的内部定量。冷EI的GC-MS具有很好的灵敏度，可用于CBD相关产品中δ9-THC的浓度测定。最后，对以色列用于治疗癫痫和自闭症谱系障碍（ASD）儿童的EP-1等大麻药物的大麻素含量进行了分析，以了解环境效应和优化药物活性。

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