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首页> 外文期刊>Journal of Medical Virology >High prevalence of HBV infection, detection of subgenotypes F1b, A2, and D4, and differential risk factors among Mexican risk populations with low socioeconomic status
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High prevalence of HBV infection, detection of subgenotypes F1b, A2, and D4, and differential risk factors among Mexican risk populations with low socioeconomic status

机译：HBV感染的高患病率，检测亚因素F1B，A2和D4，以及具有低社会经济地位的墨西哥风险群体中的差异风险因素

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Hepatitis B virus (HBV) infection may be underestimated among high-risk individuals in regions of low HBs antigenemia. This study aimed to assess HBV serological markers, genotypes, and risk factors in Mexican patients with risk of HBV infection and low socioeconomic status. Demographics, clinical, and risk factor data were collected in patients with HIV (n = 289), HCV (n = 243), deferred blood donors (D-BD) (n = 83), and two native populations, Mixtecos (n = 57) and Purepechas (n = 44). HBV infection was assessed by HBsAg, anti-HBc, and HBV-DNA testing. Overall, patients had low education and very-low income. Totally, HBsAg prevalence was 16.5% (113/684) ranging from 0.7% (HCV) to 37.3% (D-BD), while anti-HBc was 30.2% (207/684). Among 52 sequences, genotypes H (n = 34, 65.4%), G (n = 4, 7.7%), subgenotypes F1b (n = 7, 13.5%), A2 (n = 6, 11.5%), and D4 (n = 1, 1.9%) were detected. Surgeries, sexual promiscuity, and blood transfusions had a differential pattern of distribution. In HCV patients, single (OR = 5.84, 95%CI 1.91-17.80, P = 0.002), MSM (OR = 4.80, 95%CI 0.75-30.56, P = 0.097), and IDU (OR = 2.93, 95%CI 1.058-8.09, P = 0.039) were predictors for HBV infection. While IDU (OR = 2.68, 95%CI 1.08-6.61, P = 0.033) and MSM (OR = 2.64, 95%CI 1.39-5.04, P = 0.003) were predictors in HIV patients. In this group, MSM was associated with HBsAg positivity (OR = 3.45, 95%CI 1.48-8.07, P = 0.004) and IDU with anti-HBc positivity (OR = 5.12, 95%CI 2.05-12.77, P < 0.001). In conclusion, testing with a combined approach of three different HBV markers, a high prevalence of HBV infection, a differential distribution of HBV genotypes, including subgenotypes F1b, A2, and D4, as well as risk factors in low-income Mexican risk groups were detected.
机译：在低HBs抗原血症地区的高危人群中，乙型肝炎病毒（HBV）感染可能被低估。本研究旨在评估墨西哥HBV感染风险和低社会经济地位患者的HBV血清学标志物、基因型和风险因素。在HIV（n=289）、HCV（n=243）、延迟献血者（D-BD）（n=83）和两个本地人群Mixtecos（n=57）和Purepechas（n=44）中收集人口统计学、临床和风险因素数据。HBV感染通过HBsAg、抗HBc和HBV-DNA检测进行评估。总的来说，患者受教育程度低，收入很低。总的来说，HBsAg的患病率为16.5%（113/684），范围为0.7%（HCV）至37.3%（D-BD），而抗-HBc的患病率为30.2%（207/684）。在52个序列中，检测到H基因型（n=34,65.4%）、G基因型（n=4,7.7%）、F1b亚型（n=7,13.5%）、A2亚型（n=6,11.5%）和D4亚型（n=1,1.9%）。手术、性滥交和输血有不同的分布模式。在HCV患者中，单一（OR=5.84，95%CI 1.91-17.80，P=0.002）、男男性接触者（OR=4.80，95%CI 0.75-30.56，P=0.097）和注射吸毒者（OR=2.93，95%CI 1.058-8.09，P=0.039）是HBV感染的预测因子。而IDU（OR=2.68，95%可信区间1.08-6.61，P=0.033）和MSM（OR=2.64，95%可信区间1.39-5.04，P=0.003）是HIV患者的预测因子。在该组中，MSM与HBsAg阳性相关（OR=3.45，95%可信区间1.48-8.07，P=0.004），IDU与抗HBc阳性相关（OR=5.12，95%可信区间2.05-12.77，P<0.001）。综上所述，采用三种不同HBV标志物的联合方法进行检测，可以检测出HBV感染的高患病率、HBV基因型（包括F1b、A2和D4亚型）的差异分布，以及墨西哥低收入风险人群中的风险因素。

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