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首页> 外文期刊>The Tohoku Journal of Experimental Medicine >Predictors of SARS-CoV-2 Positivity Based on RT-PCR Swab Tests at a Drive-Through Outpatient Clinic for COVID-19 Screening in Japan
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Predictors of SARS-CoV-2 Positivity Based on RT-PCR Swab Tests at a Drive-Through Outpatient Clinic for COVID-19 Screening in Japan

机译：基于RT-PCR拭子试验的SARS-COV-2阳性预测因子在日本Covid-19筛选的通过门诊诊所的RT-PCR拭子试验

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摘要

In response to the COVID-19 pandemic caused by SARS-CoV-2 in 2020, we conducted drive-through nasopharyngeal swab testing for COVID-19 in Sendai city, Japan, since April 2020. All tested individuals were judged in advance by public health centers for the necessity of undergoing the test with possible contact history and/or symptoms suggestive of COVID-19. In this study, to identify the predictors of SARS-CoV-2 test positivity for more efficient and evidenced selection of suspected individuals, we enrolled 3,540 consecutive individuals, tested in the first 7 months of the testing program, with data regarding to the history of close contact with COVID-19 patients, including those involved in cluster outbreaks. This cohort included 284 foreign students (257 males and 27 females) from a vocational school involved in the largest cluster outbreak in the area. Close contact history was present in 952 (26.9%) of the participants. The reverse transcription-polymerase chain reaction (RT-PCR) test results showed that 164 participants (4.6%) were positive and 3,376 participants (95.4%) were negative for the SARS-CoV-2 nucleocapsid gene (N2). In the univariate and multivariate analyses, history of close contact with COVID-19 patients, higher age, cough symptoms, and non-native ethnicity were predictors for SARS-CoV-2 test positivity. However, the significance of age and foreign nationality disappeared or declined upon excluding the foreign students from the aforementioned largest cluster outbreak. In conclusion, a history of close contact with COVID-19 patients and the presence of cough symptoms are significant predictors of SARS-CoV-2 test positivity.
机译：为了应对2019冠状病毒疾病引起的2019冠状病毒疾病，我们于2020年4月在日本仙台市进行了鼻咽拭子检测。所有测试的2019冠状病毒疾病都由公共卫生中心预先判断，因为有可能接触COVID-19的症状和/或症状。在这项研究2019冠状病毒疾病的筛查中，为了更有效、更有效地选择可疑个体，我们对SARS COV-2试验阳性的预测因子进行了研究，我们在试验计划的前7个月中，连续3540次检测了与COVID-19患者密切接触的历史，包括那些参与群集爆发的患者。这一队列包括284名外国学生（257名男性和27名女性），他们来自一所职业学校，参与了该地区最大的集群疫情。952名参与者（26.9%）有密切接触史。逆转录聚合酶链反应（RT-PCR）检测结果显示，164名参与者（4.6%）SARS-CoV-2核衣壳基因（N2）呈阳性，3376名参与者（95.4%）呈阴性。在2019冠状病毒疾病患者的单因素和多因素分析中，与COVID-19患者密切接触的历史、年龄、咳嗽症状和非本地种族是SARS COV-2试验阳性的预测因素。然而，在将外国学生排除在上述最大群体疫情之外后，年龄和外国国籍的重要性消失或下降。总之，与2019冠状病毒疾病密切接触的患者和咳嗽症状的存在是SARS COV-2试验阳性的重要预测因素。

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